Food additives are substances that become part of food products either directly or indirectly during processing, storage or packaging. Their use has increased in recent years as a consequence of increased use of processed foods. Moreover, economical and trade reasons have brought about a large diffusion of food additives use, especially regarding the maintaining of product quality, freshness and appealing. It is well known that several food additives (nitrites, nitrates, sulphites, etc.) maybe harmful for humans; moreover, the combination of different substances in the same food product could cause the formation of unwanted compounds (i.e. nitrosamines). For these reasons, the topic "food additives in foodstuffs" is become an emerging issue in food safety. This topic would include the most interesting studies about risk assessment and innovative analytical methods relating to food additives, with a particular focus on the new frontier in food safety and technology, which is the development of innovative food processing for food additives replacement in foodstuffs.