Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report

Vasudha Nassa; Nandini N. M.; Sushma K. L.; Sapna Patel; Manjunath G. V.

doi:doi:10.11648/j.sjcm.s.2015040401.18

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Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report

Vasudha Nassa, Nandini N. M., Sushma K. L., Sapna Patel, Manjunath G. V.

Published in Science Journal of Clinical Medicine (Volume 4, Issue 4-1)

Received: 1 July 2015 Accepted: 3 July 2015 Published: 3 August 2015

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Abstract

A 54 years male patient presenting with multiple complaints was found to have large pericardial effusion leading to tamponade. Radiological findings were suggestive of a right adrenal mass. Cytological evaluation of the pericardial fluid revealed features of malignant effusion. Adrenocortical origin of the malignant cells was confirmed by immunostaining with A103 antibody against Melan-A. Hence, identification of primary lesion and confirmation of diagnosis was achieved by cytology with the help of immunohistochemistry performed on the cell block obtained from the drained pericardial fluid.

Published in	Science Journal of Clinical Medicine (Volume 4, Issue 4-1) This article belongs to the Special Issue Latest Different Concepts of Gynaecology
DOI	10.11648/j.sjcm.s.2015040401.18
Page(s)	31-35
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Melan-A, Adrenocortical Carcinoma, Malignant Pericardial effusion, Cytology, Immunohistochemistry

References

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[2]	Ng L, Libertino JM: Adrenocortical carcinoma: diagnosis, evaluation and treatment. J Urol , 169:5-11,2003.
[3]	Nakata A, Yagi S, Oyama K, Kida H, Sugioka G: Adrenocortical carcinoma with a Giant Pericardial Mass. Internal Medicine,32:438 – 440, 1993.
[4]	Ghorab, Zeina MD; Jorda, Merce MD, PhD; Ganjei, Parvin MD; Mehrdad MD: Melan A ( A103 ) Is Expressed in Adrenocortical Neoplasms but Not in Renal Cell and Hepatocellular Carcinomas. Applied immunohistochemistry and molecular morphology,11:330-333,2003.
[5]	Brennan MF. Adrenocortical Carcinoma . CA Cancer J Clin,37:348-65,1987.
[6]	Norton JA, Levin B, Jensen RT. Cancer of the endocrine system: the adrenal gland. DeVita VT Jr., Hellman S, Rosenberg SA (eds), Cancer: Principles and Practice of Oncology. Philadelphia, PA: JB Lippincott,1352-71,1993.
[7]	Page DL, DeLellis RA, Hough AJ. Tumors of the adrenal (monograph) In: Atlas of Tumor Pathology, Washington D.C.: AFIP; 1986.
[8]	Lutin JP, Cerdas S, Billiaud L, Thomas G, Gilhaume B, Bertagna X, Laudat MH, Louvel A, Chapuis Y and Blondeau P. Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy. N Engl J Med,322: 1195-1201,1990.
[9]	Rosen B, Rozenman Y, Harpaz D: Extension of adrenocortical carcinoma into the right atrium - echocardiographic diagnosis: A case report. Cardiovascular Ultrasound, 1:5,2003.
[10]	Shivakumar S. Udasimath; Surekha U. Arakeril; Mahesh H. Karigowdar; B. R. Yelikar: The Role of the Cell Block Method in the Diagnosis of Malignant Ascitic Fluid Effusions. JCDR:6(7)1280-1283,2012.
[11]	David G. Meyers; Rayma E. Meyers; Thomas W. Prendergast: The Usefulness of Diagnostic Tests on Pericardial Fluid. Chest,111(5):1213-1221,1997.
[12]	Zhang P.J. ,M.D.; Gnerga E.M.,M.D.;Tomaszewski J.E. ,M.D.; Pasha T.L.,B.S.; LiVolsi V.A., M.D. The Role oc Calretinin. Inhibin, Melan-A, BCL-2, and C-Kit in Differentiating Adrenal Cortical and Medullary Tumors: An Immunohistochemical Study. Mod Pathol, 16(6):591-597,2003.

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Vasudha Nassa, Nandini N. M., Sushma K. L., Sapna Patel, Manjunath G. V. (2015). Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report. Science Journal of Clinical Medicine, 4(4-1), 31-35. https://doi.org/10.11648/j.sjcm.s.2015040401.18

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ACS Style

Vasudha Nassa; Nandini N. M.; Sushma K. L.; Sapna Patel; Manjunath G. V. Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report. Sci. J. Clin. Med. 2015, 4(4-1), 31-35. doi: 10.11648/j.sjcm.s.2015040401.18

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AMA Style

Vasudha Nassa, Nandini N. M., Sushma K. L., Sapna Patel, Manjunath G. V. Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report. Sci J Clin Med. 2015;4(4-1):31-35. doi: 10.11648/j.sjcm.s.2015040401.18

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@article{10.11648/j.sjcm.s.2015040401.18,
  author = {Vasudha Nassa and Nandini N. M. and Sushma K. L. and Sapna Patel and Manjunath G. V.},
  title = {Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report},
  journal = {Science Journal of Clinical Medicine},
  volume = {4},
  number = {4-1},
  pages = {31-35},
  doi = {10.11648/j.sjcm.s.2015040401.18},
  url = {https://doi.org/10.11648/j.sjcm.s.2015040401.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.s.2015040401.18},
  abstract = {A 54 years male patient presenting with multiple complaints was found to have large pericardial effusion leading to tamponade. Radiological findings were suggestive of a right adrenal mass. Cytological evaluation of the pericardial fluid revealed features of malignant effusion. Adrenocortical origin of the malignant cells was confirmed by immunostaining with A103 antibody against Melan-A. Hence, identification of primary lesion and confirmation of diagnosis was achieved by cytology with the help of immunohistochemistry performed on the cell block obtained from the drained pericardial fluid.},
 year = {2015}
}

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TY  - JOUR
T1  - Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report
AU  - Vasudha Nassa
AU  - Nandini N. M.
AU  - Sushma K. L.
AU  - Sapna Patel
AU  - Manjunath G. V.
Y1  - 2015/08/03
PY  - 2015
N1  - https://doi.org/10.11648/j.sjcm.s.2015040401.18
DO  - 10.11648/j.sjcm.s.2015040401.18
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 31
EP  - 35
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.s.2015040401.18
AB  - A 54 years male patient presenting with multiple complaints was found to have large pericardial effusion leading to tamponade. Radiological findings were suggestive of a right adrenal mass. Cytological evaluation of the pericardial fluid revealed features of malignant effusion. Adrenocortical origin of the malignant cells was confirmed by immunostaining with A103 antibody against Melan-A. Hence, identification of primary lesion and confirmation of diagnosis was achieved by cytology with the help of immunohistochemistry performed on the cell block obtained from the drained pericardial fluid.
VL  - 4
IS  - 4-1
ER  -

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Author Information

Vasudha Nassa

Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India
Nandini N. M.

Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India
Sushma K. L.

Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India
Sapna Patel

Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India
Manjunath G. V.

Department of Pathology, JSS Medical College, Constituent College of JSS University, Mysore,Karnataka, India

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Plain Text BibTeX RIS

APA Style

Vasudha Nassa, Nandini N. M., Sushma K. L., Sapna Patel, Manjunath G. V. (2015). Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report. Science Journal of Clinical Medicine, 4(4-1), 31-35. https://doi.org/10.11648/j.sjcm.s.2015040401.18

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ACS Style

Vasudha Nassa; Nandini N. M.; Sushma K. L.; Sapna Patel; Manjunath G. V. Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report. Sci. J. Clin. Med. 2015, 4(4-1), 31-35. doi: 10.11648/j.sjcm.s.2015040401.18

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AMA Style

Vasudha Nassa, Nandini N. M., Sushma K. L., Sapna Patel, Manjunath G. V. Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report. Sci J Clin Med. 2015;4(4-1):31-35. doi: 10.11648/j.sjcm.s.2015040401.18

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@article{10.11648/j.sjcm.s.2015040401.18,
  author = {Vasudha Nassa and Nandini N. M. and Sushma K. L. and Sapna Patel and Manjunath G. V.},
  title = {Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report},
  journal = {Science Journal of Clinical Medicine},
  volume = {4},
  number = {4-1},
  pages = {31-35},
  doi = {10.11648/j.sjcm.s.2015040401.18},
  url = {https://doi.org/10.11648/j.sjcm.s.2015040401.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.s.2015040401.18},
  abstract = {A 54 years male patient presenting with multiple complaints was found to have large pericardial effusion leading to tamponade. Radiological findings were suggestive of a right adrenal mass. Cytological evaluation of the pericardial fluid revealed features of malignant effusion. Adrenocortical origin of the malignant cells was confirmed by immunostaining with A103 antibody against Melan-A. Hence, identification of primary lesion and confirmation of diagnosis was achieved by cytology with the help of immunohistochemistry performed on the cell block obtained from the drained pericardial fluid.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Metastasis of Adrenocortical Carcinoma to Pericardial Fluid, Cytological Diagnosis (IHC) – A Case Report
AU  - Vasudha Nassa
AU  - Nandini N. M.
AU  - Sushma K. L.
AU  - Sapna Patel
AU  - Manjunath G. V.
Y1  - 2015/08/03
PY  - 2015
N1  - https://doi.org/10.11648/j.sjcm.s.2015040401.18
DO  - 10.11648/j.sjcm.s.2015040401.18
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 31
EP  - 35
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.s.2015040401.18
AB  - A 54 years male patient presenting with multiple complaints was found to have large pericardial effusion leading to tamponade. Radiological findings were suggestive of a right adrenal mass. Cytological evaluation of the pericardial fluid revealed features of malignant effusion. Adrenocortical origin of the malignant cells was confirmed by immunostaining with A103 antibody against Melan-A. Hence, identification of primary lesion and confirmation of diagnosis was achieved by cytology with the help of immunohistochemistry performed on the cell block obtained from the drained pericardial fluid.
VL  - 4
IS  - 4-1
ER  -

Copy | Download