Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component

Mohamed Salah Abdelhamid; Ahmed Mohamed Sadat; Mohamed Salah Abdelbasset; Amr Mohamed Aly Mohamed; Hesham y Ahmed Abdel Wahab Nafad; Khald Mohamed Shawky; Solafa Amin Abdelaziz; Lobna Omar El Farouk Abd Elsalam; Mahmoud Ahmed Negida; Reham Shehab El Nemr Esmail; Adel Morad Abdellah; Ahmed Zaki Gharib

doi:doi:10.11648/j.js.20140206.16

Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component

Mohamed Salah Abdelhamid, Ahmed Mohamed Sadat, Mohamed Salah Abdelbasset, Amr Mohamed Aly Mohamed, Hesham y Ahmed Abdel Wahab Nafad, Khald Mohamed Shawky, Solafa Amin Abdelaziz, Lobna Omar El Farouk Abd Elsalam, Mahmoud Ahmed Negida, Reham Shehab El Nemr Esmail, Adel Morad Abdellah, Ahmed Zaki Gharib

Published in Journal of Surgery (Volume 2, Issue 6)

Received: 9 December 2014 Accepted: 19 December 2014 Published: 27 December 2014

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Abstract

Aims: We are trying to understand the role of HER 2 neu in tumor progression. Study design: Prospective study. Place and duration: Conducted at Bani Swif and Kasr AL Aini university hospitals between May 2013 and May 2014. Methodology: 32 patients were enrolled in the study. The speceimens were obtained surgically .Expression of HER-2-neu receptors done aided with Dako Code No. A0485. Results: In the study there were 15 cases with pure invasive carcinoma and 17 cases with in situ component , there were more positive cases (59%) with HER-2-neu in the invasive associated with in situ group than those in the pure invasive group (20%), this was statistically significant (P<0.016). Conclusion: In conclusion, it may be assumed that during cells of the in situ component are acquiring invasiveness, they partly loose Her-2-neu over expression The high percent of positive HER-2-neu in cases associated with in situ component point an arrow with question mark towards possible changes in the tumor cell biology or the actual cell line of the in situ and the invasive components.

Published in	Journal of Surgery (Volume 2, Issue 6)
DOI	10.11648/j.js.20140206.16
Page(s)	105-108
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Mammary, Invasive, In Situ, Carcinoma

References

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APA Style

Mohamed Salah Abdelhamid, Ahmed Mohamed Sadat, Mohamed Salah Abdelbasset, Amr Mohamed Aly Mohamed, Hesham y Ahmed Abdel Wahab Nafad, et al. (2014). Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component. Journal of Surgery, 2(6), 105-108. https://doi.org/10.11648/j.js.20140206.16

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ACS Style

Mohamed Salah Abdelhamid; Ahmed Mohamed Sadat; Mohamed Salah Abdelbasset; Amr Mohamed Aly Mohamed; Hesham y Ahmed Abdel Wahab Nafad, et al. Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component. J. Surg. 2014, 2(6), 105-108. doi: 10.11648/j.js.20140206.16

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AMA Style

Mohamed Salah Abdelhamid, Ahmed Mohamed Sadat, Mohamed Salah Abdelbasset, Amr Mohamed Aly Mohamed, Hesham y Ahmed Abdel Wahab Nafad, et al. Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component. J Surg. 2014;2(6):105-108. doi: 10.11648/j.js.20140206.16

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@article{10.11648/j.js.20140206.16,
  author = {Mohamed Salah Abdelhamid and Ahmed Mohamed Sadat and Mohamed Salah Abdelbasset and Amr Mohamed Aly Mohamed and Hesham y Ahmed Abdel Wahab Nafad and Khald Mohamed Shawky and Solafa Amin Abdelaziz and Lobna Omar El Farouk Abd Elsalam and Mahmoud Ahmed Negida and Reham Shehab El Nemr Esmail and Adel Morad Abdellah and Ahmed Zaki Gharib},
  title = {Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component},
  journal = {Journal of Surgery},
  volume = {2},
  number = {6},
  pages = {105-108},
  doi = {10.11648/j.js.20140206.16},
  url = {https://doi.org/10.11648/j.js.20140206.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20140206.16},
  abstract = {Aims: We are trying to understand the role of HER 2 neu in tumor progression. Study design: Prospective study. Place and duration: Conducted at Bani Swif and Kasr AL Aini university hospitals between May 2013 and May 2014. Methodology: 32 patients were enrolled in the study. The speceimens were obtained surgically .Expression of HER-2-neu receptors done aided with Dako Code No. A0485. Results: In the study there were 15 cases with pure invasive carcinoma and 17 cases with in situ component , there were more positive cases (59%) with HER-2-neu in the invasive associated with in situ group than those in the pure invasive group (20%), this was statistically significant (P<0.016). Conclusion: In conclusion, it may be assumed that during cells of the in situ component are acquiring invasiveness, they partly loose Her-2-neu over expression The high percent of positive HER-2-neu in cases associated with in situ component point an arrow with question mark towards possible changes in the tumor cell biology or the actual cell line of the in situ and the invasive components.},
 year = {2014}
}

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TY  - JOUR
T1  - Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component
AU  - Mohamed Salah Abdelhamid
AU  - Ahmed Mohamed Sadat
AU  - Mohamed Salah Abdelbasset
AU  - Amr Mohamed Aly Mohamed
AU  - Hesham y Ahmed Abdel Wahab Nafad
AU  - Khald Mohamed Shawky
AU  - Solafa Amin Abdelaziz
AU  - Lobna Omar El Farouk Abd Elsalam
AU  - Mahmoud Ahmed Negida
AU  - Reham Shehab El Nemr Esmail
AU  - Adel Morad Abdellah
AU  - Ahmed Zaki Gharib
Y1  - 2014/12/27
PY  - 2014
N1  - https://doi.org/10.11648/j.js.20140206.16
DO  - 10.11648/j.js.20140206.16
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 105
EP  - 108
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20140206.16
AB  - Aims: We are trying to understand the role of HER 2 neu in tumor progression. Study design: Prospective study. Place and duration: Conducted at Bani Swif and Kasr AL Aini university hospitals between May 2013 and May 2014. Methodology: 32 patients were enrolled in the study. The speceimens were obtained surgically .Expression of HER-2-neu receptors done aided with Dako Code No. A0485. Results: In the study there were 15 cases with pure invasive carcinoma and 17 cases with in situ component , there were more positive cases (59%) with HER-2-neu in the invasive associated with in situ group than those in the pure invasive group (20%), this was statistically significant (P<0.016). Conclusion: In conclusion, it may be assumed that during cells of the in situ component are acquiring invasiveness, they partly loose Her-2-neu over expression The high percent of positive HER-2-neu in cases associated with in situ component point an arrow with question mark towards possible changes in the tumor cell biology or the actual cell line of the in situ and the invasive components.
VL  - 2
IS  - 6
ER  -

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Author Information

Mohamed Salah Abdelhamid

Bani Suef Faculty of Medicine, Bani Suef University, Egypt
Ahmed Mohamed Sadat

Bani Suef Faculty of Medicine, Bani Suef University, Egypt
Mohamed Salah Abdelbasset

Bani Suef Faculty of Medicine, Bani Suef University, Egypt
Amr Mohamed Aly Mohamed

Bani Suef Faculty of Medicine, Bani Suef University, Egypt
Hesham y Ahmed Abdel Wahab Nafad

Bani Suef Faculty of Medicine, Bani Suef University, Egypt
Khald Mohamed Shawky

Bani Suef Faculty of Medicine, Bani Suef University, Egypt
Solafa Amin Abdelaziz

Kasr El Aini Faculty of Medicine, Cairo University, Egypt
Lobna Omar El Farouk Abd Elsalam

Kasr El Aini Faculty of Medicine, Cairo University, Egypt
Mahmoud Ahmed Negida

Kasr El Aini Faculty of Medicine, Cairo University, Egypt
Reham Shehab El Nemr Esmail

National Research Center, Cairo University, Egypt
Adel Morad Abdellah

October 6th Faculty of Medicine, October 6th University, Cairo, Egypt
Ahmed Zaki Gharib

October 6th Faculty of Medicine, October 6th University, Cairo, Egypt

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Plain Text BibTeX RIS

APA Style

Mohamed Salah Abdelhamid, Ahmed Mohamed Sadat, Mohamed Salah Abdelbasset, Amr Mohamed Aly Mohamed, Hesham y Ahmed Abdel Wahab Nafad, et al. (2014). Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component. Journal of Surgery, 2(6), 105-108. https://doi.org/10.11648/j.js.20140206.16

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ACS Style

Mohamed Salah Abdelhamid; Ahmed Mohamed Sadat; Mohamed Salah Abdelbasset; Amr Mohamed Aly Mohamed; Hesham y Ahmed Abdel Wahab Nafad, et al. Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component. J. Surg. 2014, 2(6), 105-108. doi: 10.11648/j.js.20140206.16

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AMA Style

Mohamed Salah Abdelhamid, Ahmed Mohamed Sadat, Mohamed Salah Abdelbasset, Amr Mohamed Aly Mohamed, Hesham y Ahmed Abdel Wahab Nafad, et al. Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component. J Surg. 2014;2(6):105-108. doi: 10.11648/j.js.20140206.16

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@article{10.11648/j.js.20140206.16,
  author = {Mohamed Salah Abdelhamid and Ahmed Mohamed Sadat and Mohamed Salah Abdelbasset and Amr Mohamed Aly Mohamed and Hesham y Ahmed Abdel Wahab Nafad and Khald Mohamed Shawky and Solafa Amin Abdelaziz and Lobna Omar El Farouk Abd Elsalam and Mahmoud Ahmed Negida and Reham Shehab El Nemr Esmail and Adel Morad Abdellah and Ahmed Zaki Gharib},
  title = {Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component},
  journal = {Journal of Surgery},
  volume = {2},
  number = {6},
  pages = {105-108},
  doi = {10.11648/j.js.20140206.16},
  url = {https://doi.org/10.11648/j.js.20140206.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20140206.16},
  abstract = {Aims: We are trying to understand the role of HER 2 neu in tumor progression. Study design: Prospective study. Place and duration: Conducted at Bani Swif and Kasr AL Aini university hospitals between May 2013 and May 2014. Methodology: 32 patients were enrolled in the study. The speceimens were obtained surgically .Expression of HER-2-neu receptors done aided with Dako Code No. A0485. Results: In the study there were 15 cases with pure invasive carcinoma and 17 cases with in situ component , there were more positive cases (59%) with HER-2-neu in the invasive associated with in situ group than those in the pure invasive group (20%), this was statistically significant (P<0.016). Conclusion: In conclusion, it may be assumed that during cells of the in situ component are acquiring invasiveness, they partly loose Her-2-neu over expression The high percent of positive HER-2-neu in cases associated with in situ component point an arrow with question mark towards possible changes in the tumor cell biology or the actual cell line of the in situ and the invasive components.},
 year = {2014}
}

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TY  - JOUR
T1  - Over Expression of HER2/Neu in Female Ductal Carcinoma: Pure Invasive Versus Invasive with in Situ Component
AU  - Mohamed Salah Abdelhamid
AU  - Ahmed Mohamed Sadat
AU  - Mohamed Salah Abdelbasset
AU  - Amr Mohamed Aly Mohamed
AU  - Hesham y Ahmed Abdel Wahab Nafad
AU  - Khald Mohamed Shawky
AU  - Solafa Amin Abdelaziz
AU  - Lobna Omar El Farouk Abd Elsalam
AU  - Mahmoud Ahmed Negida
AU  - Reham Shehab El Nemr Esmail
AU  - Adel Morad Abdellah
AU  - Ahmed Zaki Gharib
Y1  - 2014/12/27
PY  - 2014
N1  - https://doi.org/10.11648/j.js.20140206.16
DO  - 10.11648/j.js.20140206.16
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 105
EP  - 108
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20140206.16
AB  - Aims: We are trying to understand the role of HER 2 neu in tumor progression. Study design: Prospective study. Place and duration: Conducted at Bani Swif and Kasr AL Aini university hospitals between May 2013 and May 2014. Methodology: 32 patients were enrolled in the study. The speceimens were obtained surgically .Expression of HER-2-neu receptors done aided with Dako Code No. A0485. Results: In the study there were 15 cases with pure invasive carcinoma and 17 cases with in situ component , there were more positive cases (59%) with HER-2-neu in the invasive associated with in situ group than those in the pure invasive group (20%), this was statistically significant (P<0.016). Conclusion: In conclusion, it may be assumed that during cells of the in situ component are acquiring invasiveness, they partly loose Her-2-neu over expression The high percent of positive HER-2-neu in cases associated with in situ component point an arrow with question mark towards possible changes in the tumor cell biology or the actual cell line of the in situ and the invasive components.
VL  - 2
IS  - 6
ER  -

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