Aims: Helicobacter pylori was found in the bile and gallbladder, so we are aiming to examine the relationship between H. pylori-like bacteria and chronic calcular cholecystitis. METHODS: This cross-sectional study was conducted at our hospitals from May 2011 to January 2012. One hundred and forty patients with chronic calcular cholecystitis were enrolled in this study. Gastroscopy with gastric or duodenal H.pylori urease test and detection of H. pylori in serum were done before the surgical procedure for all patients. After cholecystectomy, the gallbladder tissue was investigated for H. pylori by rapid urease test and Geimsa stain. RESULTS: Of all 140 patients 62.1 % were females, mean age of our patients was 39.04 ± 7.3 years. H. pylori IgG antibody titre was positive in 32 patients with biliary duodenitis, in 43 patients with biliary gastritis, and in 18 patients with duodenal ulcer. The gastric rapid urease test was positive in 40.7 %. The gallbladder rapid urease test was positive in 25 %. In 24 patients both gastric and gallbladder mucosa tested positive for rapid urease test. In 28 patients, the gastric urease test was positive while the gallbladder mucosa tested negative. In 13 patients, the gallbladder mucosa tested positive while the gastric mucosa was negative. There was a significant correlation between the rapid urease test in the gallbladder and in the gastric or duodenal mucosa (P = 0.002). Modified Geimsa staining of gallbladder specimens revealed that H. pylori-like bacteria were detected in 63.6 %. There was a significant correlation between histopathological examination of gallbladder mucosa stained with Geimsa stain and the gallbladder rapid urease test (P < 0.001), but not correlated with the gastric urease test (P = 0.210). CONCLUSION: Our study demonstrates that H. pylori is present in the gallbladder mucosa in patients with chronic calcular cholecystitis and might be an etiological cause of chronic inflammation`.
| Published in | Journal of Surgery (Volume 2, Issue 4) |
| DOI | 10.11648/j.js.20140204.12 |
| Page(s) | 58-62 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Cholecystitis, Helicobacter Pylori, Urease Test
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APA Style
Amir A. Fikry, Arafat A. Kassem, Doaa Shahin, Hosam Aldeen Salah Shabana, Sadek Mostafa. (2014). Helicobacter Pylori Infection in Patients with Chronic Calcular Cholecystitis a Cross- Sectional Study. Journal of Surgery, 2(4), 58-62. https://doi.org/10.11648/j.js.20140204.12
ACS Style
Amir A. Fikry; Arafat A. Kassem; Doaa Shahin; Hosam Aldeen Salah Shabana; Sadek Mostafa. Helicobacter Pylori Infection in Patients with Chronic Calcular Cholecystitis a Cross- Sectional Study. J. Surg. 2014, 2(4), 58-62. doi: 10.11648/j.js.20140204.12
AMA Style
Amir A. Fikry, Arafat A. Kassem, Doaa Shahin, Hosam Aldeen Salah Shabana, Sadek Mostafa. Helicobacter Pylori Infection in Patients with Chronic Calcular Cholecystitis a Cross- Sectional Study. J Surg. 2014;2(4):58-62. doi: 10.11648/j.js.20140204.12
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Download@article{10.11648/j.js.20140204.12,
author = {Amir A. Fikry and Arafat A. Kassem and Doaa Shahin and Hosam Aldeen Salah Shabana and Sadek Mostafa},
title = {Helicobacter Pylori Infection in Patients with Chronic Calcular Cholecystitis a Cross- Sectional Study},
journal = {Journal of Surgery},
volume = {2},
number = {4},
pages = {58-62},
doi = {10.11648/j.js.20140204.12},
url = {https://doi.org/10.11648/j.js.20140204.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20140204.12},
abstract = {Aims: Helicobacter pylori was found in the bile and gallbladder, so we are aiming to examine the relationship between H. pylori-like bacteria and chronic calcular cholecystitis. METHODS: This cross-sectional study was conducted at our hospitals from May 2011 to January 2012. One hundred and forty patients with chronic calcular cholecystitis were enrolled in this study. Gastroscopy with gastric or duodenal H.pylori urease test and detection of H. pylori in serum were done before the surgical procedure for all patients. After cholecystectomy, the gallbladder tissue was investigated for H. pylori by rapid urease test and Geimsa stain. RESULTS: Of all 140 patients 62.1 % were females, mean age of our patients was 39.04 ± 7.3 years. H. pylori IgG antibody titre was positive in 32 patients with biliary duodenitis, in 43 patients with biliary gastritis, and in 18 patients with duodenal ulcer. The gastric rapid urease test was positive in 40.7 %. The gallbladder rapid urease test was positive in 25 %. In 24 patients both gastric and gallbladder mucosa tested positive for rapid urease test. In 28 patients, the gastric urease test was positive while the gallbladder mucosa tested negative. In 13 patients, the gallbladder mucosa tested positive while the gastric mucosa was negative. There was a significant correlation between the rapid urease test in the gallbladder and in the gastric or duodenal mucosa (P = 0.002). Modified Geimsa staining of gallbladder specimens revealed that H. pylori-like bacteria were detected in 63.6 %. There was a significant correlation between histopathological examination of gallbladder mucosa stained with Geimsa stain and the gallbladder rapid urease test (P < 0.001), but not correlated with the gastric urease test (P = 0.210). CONCLUSION: Our study demonstrates that H. pylori is present in the gallbladder mucosa in patients with chronic calcular cholecystitis and might be an etiological cause of chronic inflammation`.},
year = {2014}
}
TY - JOUR T1 - Helicobacter Pylori Infection in Patients with Chronic Calcular Cholecystitis a Cross- Sectional Study AU - Amir A. Fikry AU - Arafat A. Kassem AU - Doaa Shahin AU - Hosam Aldeen Salah Shabana AU - Sadek Mostafa Y1 - 2014/08/20 PY - 2014 N1 - https://doi.org/10.11648/j.js.20140204.12 DO - 10.11648/j.js.20140204.12 T2 - Journal of Surgery JF - Journal of Surgery JO - Journal of Surgery SP - 58 EP - 62 PB - Science Publishing Group SN - 2330-0930 UR - https://doi.org/10.11648/j.js.20140204.12 AB - Aims: Helicobacter pylori was found in the bile and gallbladder, so we are aiming to examine the relationship between H. pylori-like bacteria and chronic calcular cholecystitis. METHODS: This cross-sectional study was conducted at our hospitals from May 2011 to January 2012. One hundred and forty patients with chronic calcular cholecystitis were enrolled in this study. Gastroscopy with gastric or duodenal H.pylori urease test and detection of H. pylori in serum were done before the surgical procedure for all patients. After cholecystectomy, the gallbladder tissue was investigated for H. pylori by rapid urease test and Geimsa stain. RESULTS: Of all 140 patients 62.1 % were females, mean age of our patients was 39.04 ± 7.3 years. H. pylori IgG antibody titre was positive in 32 patients with biliary duodenitis, in 43 patients with biliary gastritis, and in 18 patients with duodenal ulcer. The gastric rapid urease test was positive in 40.7 %. The gallbladder rapid urease test was positive in 25 %. In 24 patients both gastric and gallbladder mucosa tested positive for rapid urease test. In 28 patients, the gastric urease test was positive while the gallbladder mucosa tested negative. In 13 patients, the gallbladder mucosa tested positive while the gastric mucosa was negative. There was a significant correlation between the rapid urease test in the gallbladder and in the gastric or duodenal mucosa (P = 0.002). Modified Geimsa staining of gallbladder specimens revealed that H. pylori-like bacteria were detected in 63.6 %. There was a significant correlation between histopathological examination of gallbladder mucosa stained with Geimsa stain and the gallbladder rapid urease test (P < 0.001), but not correlated with the gastric urease test (P = 0.210). CONCLUSION: Our study demonstrates that H. pylori is present in the gallbladder mucosa in patients with chronic calcular cholecystitis and might be an etiological cause of chronic inflammation`. VL - 2 IS - 4 ER -
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