Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women

Erika Mizutani; Sayuki Hashimoto; Hiromi Saito; Maiko Kato; Akihiro Yoshida; Michitaka Naito

doi:doi:10.11648/j.jfns.20180601.11

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Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women

Erika Mizutani, Sayuki Hashimoto, Hiromi Saito, Maiko Kato, Akihiro Yoshida, Michitaka Naito

Published in Journal of Food and Nutrition Sciences (Volume 6, Issue 1)

Received: 10 August 2017 Accepted: 9 September 2017 Published: 14 December 2017

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Abstract

Differential effects of sugars, namely sucrose, fructose, and glucose on postprandial carbohydrate and lipid metabolism were investigated in young women. Young Japanese women with normal body mass (BMI ≥18.5−<25 kg/m²) and apolipoprotein E phenotype 3/3 were enrolled. In the experiment (Exp) 1, subjects (n = 10) ingested one of the beverages containing (1) glucose (0.5 g/kg body mass), (2) fructose (0.5 g/kg), (3) sucrose (0.5 g/kg), or (4) glucose (0.25 g/kg) + fructose (0.25 g/kg) in a randomized crossover design. In Exp 2, subjects (n = 10) ingested fat cream (fat content: 0.35 g/kg) alone or along with either beverage (1), (2), or (3). Blood samples were collected at baseline and 0.5, 1, 2, 4, and 6 h after ingestion and then analyzed. In Exp 1, the ingestion of fructose non-significantly increased postprandial serum triglyceride (TG), hepatic TG-rich lipoprotein-TG, and remnant cholesterol levels. In Exp 2, coingestion of fructose or sucrose with fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response after coingestion of sucrose with fat was intermediate between that observed after coingestion of fructose with fat and that observed after coingestion of glucose with fat. In conclusion, ingestion of fructose may increase endogenous TG-rich lipoprotein concentration, but the effect of sucrose was weaker. Coingestion of fructose and fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response by sucrose coingestion with fat was intermediate between fructose and glucose.

Published in	Journal of Food and Nutrition Sciences (Volume 6, Issue 1)
DOI	10.11648/j.jfns.20180601.11
Page(s)	1-11
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Sucrose, Fructose, Glucose, Triglyceride, Remnant Lipoprotein

References

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APA Style

Erika Mizutani, Sayuki Hashimoto, Hiromi Saito, Maiko Kato, Akihiro Yoshida, et al. (2017). Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women. Journal of Food and Nutrition Sciences, 6(1), 1-11. https://doi.org/10.11648/j.jfns.20180601.11

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ACS Style

Erika Mizutani; Sayuki Hashimoto; Hiromi Saito; Maiko Kato; Akihiro Yoshida, et al. Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women. J. Food Nutr. Sci. 2017, 6(1), 1-11. doi: 10.11648/j.jfns.20180601.11

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AMA Style

Erika Mizutani, Sayuki Hashimoto, Hiromi Saito, Maiko Kato, Akihiro Yoshida, et al. Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women. J Food Nutr Sci. 2017;6(1):1-11. doi: 10.11648/j.jfns.20180601.11

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@article{10.11648/j.jfns.20180601.11,
  author = {Erika Mizutani and Sayuki Hashimoto and Hiromi Saito and Maiko Kato and Akihiro Yoshida and Michitaka Naito},
  title = {Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {6},
  number = {1},
  pages = {1-11},
  doi = {10.11648/j.jfns.20180601.11},
  url = {https://doi.org/10.11648/j.jfns.20180601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20180601.11},
  abstract = {Differential effects of sugars, namely sucrose, fructose, and glucose on postprandial carbohydrate and lipid metabolism were investigated in young women. Young Japanese women with normal body mass (BMI ≥18.5−2) and apolipoprotein E phenotype 3/3 were enrolled. In the experiment (Exp) 1, subjects (n = 10) ingested one of the beverages containing (1) glucose (0.5 g/kg body mass), (2) fructose (0.5 g/kg), (3) sucrose (0.5 g/kg), or (4) glucose (0.25 g/kg) + fructose (0.25 g/kg) in a randomized crossover design. In Exp 2, subjects (n = 10) ingested fat cream (fat content: 0.35 g/kg) alone or along with either beverage (1), (2), or (3). Blood samples were collected at baseline and 0.5, 1, 2, 4, and 6 h after ingestion and then analyzed. In Exp 1, the ingestion of fructose non-significantly increased postprandial serum triglyceride (TG), hepatic TG-rich lipoprotein-TG, and remnant cholesterol levels. In Exp 2, coingestion of fructose or sucrose with fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response after coingestion of sucrose with fat was intermediate between that observed after coingestion of fructose with fat and that observed after coingestion of glucose with fat. In conclusion, ingestion of fructose may increase endogenous TG-rich lipoprotein concentration, but the effect of sucrose was weaker. Coingestion of fructose and fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response by sucrose coingestion with fat was intermediate between fructose and glucose.},
 year = {2017}
}

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TY  - JOUR
T1  - Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women
AU  - Erika Mizutani
AU  - Sayuki Hashimoto
AU  - Hiromi Saito
AU  - Maiko Kato
AU  - Akihiro Yoshida
AU  - Michitaka Naito
Y1  - 2017/12/14
PY  - 2017
N1  - https://doi.org/10.11648/j.jfns.20180601.11
DO  - 10.11648/j.jfns.20180601.11
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 1
EP  - 11
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20180601.11
AB  - Differential effects of sugars, namely sucrose, fructose, and glucose on postprandial carbohydrate and lipid metabolism were investigated in young women. Young Japanese women with normal body mass (BMI ≥18.5−2) and apolipoprotein E phenotype 3/3 were enrolled. In the experiment (Exp) 1, subjects (n = 10) ingested one of the beverages containing (1) glucose (0.5 g/kg body mass), (2) fructose (0.5 g/kg), (3) sucrose (0.5 g/kg), or (4) glucose (0.25 g/kg) + fructose (0.25 g/kg) in a randomized crossover design. In Exp 2, subjects (n = 10) ingested fat cream (fat content: 0.35 g/kg) alone or along with either beverage (1), (2), or (3). Blood samples were collected at baseline and 0.5, 1, 2, 4, and 6 h after ingestion and then analyzed. In Exp 1, the ingestion of fructose non-significantly increased postprandial serum triglyceride (TG), hepatic TG-rich lipoprotein-TG, and remnant cholesterol levels. In Exp 2, coingestion of fructose or sucrose with fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response after coingestion of sucrose with fat was intermediate between that observed after coingestion of fructose with fat and that observed after coingestion of glucose with fat. In conclusion, ingestion of fructose may increase endogenous TG-rich lipoprotein concentration, but the effect of sucrose was weaker. Coingestion of fructose and fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response by sucrose coingestion with fat was intermediate between fructose and glucose.
VL  - 6
IS  - 1
ER  -

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Author Information

Erika Mizutani

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
Sayuki Hashimoto

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
Hiromi Saito

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
Maiko Kato

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan
Akihiro Yoshida

Department of Clinical Laboratory, Nakatsugawa Municipal General Hospital, Nakatsugawa, Japan
Michitaka Naito

Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan

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APA Style

Erika Mizutani, Sayuki Hashimoto, Hiromi Saito, Maiko Kato, Akihiro Yoshida, et al. (2017). Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women. Journal of Food and Nutrition Sciences, 6(1), 1-11. https://doi.org/10.11648/j.jfns.20180601.11

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ACS Style

Erika Mizutani; Sayuki Hashimoto; Hiromi Saito; Maiko Kato; Akihiro Yoshida, et al. Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women. J. Food Nutr. Sci. 2017, 6(1), 1-11. doi: 10.11648/j.jfns.20180601.11

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AMA Style

Erika Mizutani, Sayuki Hashimoto, Hiromi Saito, Maiko Kato, Akihiro Yoshida, et al. Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women. J Food Nutr Sci. 2017;6(1):1-11. doi: 10.11648/j.jfns.20180601.11

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@article{10.11648/j.jfns.20180601.11,
  author = {Erika Mizutani and Sayuki Hashimoto and Hiromi Saito and Maiko Kato and Akihiro Yoshida and Michitaka Naito},
  title = {Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women},
  journal = {Journal of Food and Nutrition Sciences},
  volume = {6},
  number = {1},
  pages = {1-11},
  doi = {10.11648/j.jfns.20180601.11},
  url = {https://doi.org/10.11648/j.jfns.20180601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20180601.11},
  abstract = {Differential effects of sugars, namely sucrose, fructose, and glucose on postprandial carbohydrate and lipid metabolism were investigated in young women. Young Japanese women with normal body mass (BMI ≥18.5−2) and apolipoprotein E phenotype 3/3 were enrolled. In the experiment (Exp) 1, subjects (n = 10) ingested one of the beverages containing (1) glucose (0.5 g/kg body mass), (2) fructose (0.5 g/kg), (3) sucrose (0.5 g/kg), or (4) glucose (0.25 g/kg) + fructose (0.25 g/kg) in a randomized crossover design. In Exp 2, subjects (n = 10) ingested fat cream (fat content: 0.35 g/kg) alone or along with either beverage (1), (2), or (3). Blood samples were collected at baseline and 0.5, 1, 2, 4, and 6 h after ingestion and then analyzed. In Exp 1, the ingestion of fructose non-significantly increased postprandial serum triglyceride (TG), hepatic TG-rich lipoprotein-TG, and remnant cholesterol levels. In Exp 2, coingestion of fructose or sucrose with fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response after coingestion of sucrose with fat was intermediate between that observed after coingestion of fructose with fat and that observed after coingestion of glucose with fat. In conclusion, ingestion of fructose may increase endogenous TG-rich lipoprotein concentration, but the effect of sucrose was weaker. Coingestion of fructose and fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response by sucrose coingestion with fat was intermediate between fructose and glucose.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Differential Effects of Sucrose, Fructose, and Glucose on Postprandial Carbohydrate and Lipid Metabolism in Young Japanese Women
AU  - Erika Mizutani
AU  - Sayuki Hashimoto
AU  - Hiromi Saito
AU  - Maiko Kato
AU  - Akihiro Yoshida
AU  - Michitaka Naito
Y1  - 2017/12/14
PY  - 2017
N1  - https://doi.org/10.11648/j.jfns.20180601.11
DO  - 10.11648/j.jfns.20180601.11
T2  - Journal of Food and Nutrition Sciences
JF  - Journal of Food and Nutrition Sciences
JO  - Journal of Food and Nutrition Sciences
SP  - 1
EP  - 11
PB  - Science Publishing Group
SN  - 2330-7293
UR  - https://doi.org/10.11648/j.jfns.20180601.11
AB  - Differential effects of sugars, namely sucrose, fructose, and glucose on postprandial carbohydrate and lipid metabolism were investigated in young women. Young Japanese women with normal body mass (BMI ≥18.5−2) and apolipoprotein E phenotype 3/3 were enrolled. In the experiment (Exp) 1, subjects (n = 10) ingested one of the beverages containing (1) glucose (0.5 g/kg body mass), (2) fructose (0.5 g/kg), (3) sucrose (0.5 g/kg), or (4) glucose (0.25 g/kg) + fructose (0.25 g/kg) in a randomized crossover design. In Exp 2, subjects (n = 10) ingested fat cream (fat content: 0.35 g/kg) alone or along with either beverage (1), (2), or (3). Blood samples were collected at baseline and 0.5, 1, 2, 4, and 6 h after ingestion and then analyzed. In Exp 1, the ingestion of fructose non-significantly increased postprandial serum triglyceride (TG), hepatic TG-rich lipoprotein-TG, and remnant cholesterol levels. In Exp 2, coingestion of fructose or sucrose with fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response after coingestion of sucrose with fat was intermediate between that observed after coingestion of fructose with fat and that observed after coingestion of glucose with fat. In conclusion, ingestion of fructose may increase endogenous TG-rich lipoprotein concentration, but the effect of sucrose was weaker. Coingestion of fructose and fat delayed postprandial lipidemia compared with the ingestion of fat alone. The extent of postprandial lipid response by sucrose coingestion with fat was intermediate between fructose and glucose.
VL  - 6
IS  - 1
ER  -

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