Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter

Gholamreza Atae; Seyed Rabee Mahdavi; Akram Mohammadi Nokhandani; Syede Mahsa Taheri Otaghsara; Mahboubeh Khadem Abolfazli

doi:doi:10.11648/j.ijbse.20150301.11

Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter

Gholamreza Atae, Seyed Rabee Mahdavi, Akram Mohammadi Nokhandani, Syede Mahsa Taheri Otaghsara, Mahboubeh Khadem Abolfazli

Published in International Journal of Biomedical Science and Engineering (Volume 3, Issue 1)

Received: 29 November 2014 Accepted: 16 December 2014 Published: 20 January 2015

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Abstract

Background: Polymer gels beam sensitive are valuable and confident for measurement of 3D dose distributions. One of the special features of this type of dosimeters is their tissue equivalence, which makes them appropriate for the investigation of dose enhancement with contrast agents with high atomic number. Objective: The purpose of this study is an investigating of dose enhancement dependent in energy within the gel medium with used of conformal distribution gold nanoparticle as contrast agents by high atomic number material. Methods: In this work, gold nanoparticles (GNPs) of 50nm diameter with 0.1m concentration embedded in gel and irradiated by different megavoltage energy of 18MVand 6MV photon beam. Then GN- MAGICA and MAGICA dose response curves compare and achieved dose enhancement. Results: Experimental results have shown dose enhancement factor of 6MV and 18MV in 0.1mM, concentration is 1.74 and 1.04 respectively. Conclusion: The results showed that by adding of gold nanoparticles to the MAGICA polymer gel absorbed dose is increased. The levels of polymerization of irradiated gels with and without AuNPs in energy 6MV is more than energy 18MV. It seems that because of the dominance of photoelectric effect at low energies and pair production effect at high energies.

Published in	International Journal of Biomedical Science and Engineering (Volume 3, Issue 1)
DOI	10.11648/j.ijbse.20150301.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Dose Enhancement, Polymer Gel Dosimeter, Gold Nanoparticles

References

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[3]	Mukherjee P, Bhattacharya R, Bone N, Lee YK, Patra CR, Wang S, et al. Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): enhancing apoptosis.J Nanobiotechnol2007;5:4..
[4]	Rahman WN, Bishara N, Ackerly T, et al. Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy.Nano-medicine2009;5:136-142.
[5]	Hainfeld JF, Slatkin DN, Smilowitz HM. The use of gold nanoparticles to enhance radiotherapy in mice.Phys Med Biol2004;49:N309-N315
[6]	Jain S, Coulter JA, Hounsell AR, et al. Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. Int J Radiat Oncol Biol Phys2011;79:531-539.
[7]	Baldock C, De Deene Y, Doran S, et al. Polymer gel dosimetry. Phys Med Biol2010;55:R1-R63.
[8]	Doran SJ. The history and principles of chemical dosimetry for 3-D radiation fields: gels, polymers and plastics. Appl Radiat Isotopes 2009; 67:393-398.
[9]	Butterworth KT, Coulter JA, Jain S, et al. Evaluation of cytotoxicityand radiation enhancement using 1.9 nm gold particles: potentialapplication for cancer thpy. Nanotechnology 2010; 21: 295101.
[10]	Chithrani DB, Jelveh S, Jalali F, et al. Gold nanoparticles as radiation sensitizers in cancer therapy. Radiat Res2010; 173:719-728.
[11]	Rahman WN, Bishara N, Ackerly T, et al. Enhancement of radiationeffects by gold nanoparticles for superficial radiation therapy.Nano-medicine2009;5:136-142.
[12]	Zahmatkesh MH, Kousari R, Akhlaghpour S, Bagheri SA (2004) MRI gel dosimetry with methacrylic acid, ascor‐bic acid, hydroquinon and copper in agarose (MAGICA) gel. In: Preliminary Proceedings of DOSGEL 2004; Ghent, Belgium.
[13]	Gustavsson H (2004) Radiotherapy gel dosimetry, development and application of normoxic polymer gels, [Ph.D Thesis], Malmo University Hospital, Lund University, Lund, Sweden

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Gholamreza Atae, Seyed Rabee Mahdavi, Akram Mohammadi Nokhandani, Syede Mahsa Taheri Otaghsara, Mahboubeh Khadem Abolfazli. (2015). Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter. International Journal of Biomedical Science and Engineering, 3(1), 1-4. https://doi.org/10.11648/j.ijbse.20150301.11

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ACS Style

Gholamreza Atae; Seyed Rabee Mahdavi; Akram Mohammadi Nokhandani; Syede Mahsa Taheri Otaghsara; Mahboubeh Khadem Abolfazli. Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter. Int. J. Biomed. Sci. Eng. 2015, 3(1), 1-4. doi: 10.11648/j.ijbse.20150301.11

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AMA Style

Gholamreza Atae, Seyed Rabee Mahdavi, Akram Mohammadi Nokhandani, Syede Mahsa Taheri Otaghsara, Mahboubeh Khadem Abolfazli. Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter. Int J Biomed Sci Eng. 2015;3(1):1-4. doi: 10.11648/j.ijbse.20150301.11

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@article{10.11648/j.ijbse.20150301.11,
  author = {Gholamreza Atae and Seyed Rabee Mahdavi and Akram Mohammadi Nokhandani and Syede Mahsa Taheri Otaghsara and Mahboubeh Khadem Abolfazli},
  title = {Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {3},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijbse.20150301.11},
  url = {https://doi.org/10.11648/j.ijbse.20150301.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20150301.11},
  abstract = {Background: Polymer gels beam sensitive are valuable and confident for measurement of 3D dose distributions. One of the special features of this type of dosimeters is their tissue equivalence, which makes them appropriate for the investigation of dose enhancement with contrast agents with high atomic number. Objective: The purpose of this study is an investigating of dose enhancement dependent in energy within the gel medium with used of conformal distribution gold nanoparticle as contrast agents by high atomic number material. Methods: In this work, gold nanoparticles (GNPs) of 50nm diameter with 0.1m concentration embedded in gel and irradiated by different megavoltage energy of 18MVand 6MV photon beam. Then GN- MAGICA and MAGICA dose response curves compare and achieved dose enhancement. Results: Experimental results have shown dose enhancement factor of 6MV and 18MV in 0.1mM, concentration is 1.74 and 1.04 respectively. Conclusion: The results showed that by adding of gold nanoparticles to the MAGICA polymer gel absorbed dose is increased. The levels of polymerization of irradiated gels with and without AuNPs in energy 6MV is more than energy 18MV. It seems that because of the dominance of photoelectric effect at low energies and pair production effect at high energies.},
 year = {2015}
}

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TY  - JOUR
T1  - Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter
AU  - Gholamreza Atae
AU  - Seyed Rabee Mahdavi
AU  - Akram Mohammadi Nokhandani
AU  - Syede Mahsa Taheri Otaghsara
AU  - Mahboubeh Khadem Abolfazli
Y1  - 2015/01/20
PY  - 2015
N1  - https://doi.org/10.11648/j.ijbse.20150301.11
DO  - 10.11648/j.ijbse.20150301.11
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20150301.11
AB  - Background: Polymer gels beam sensitive are valuable and confident for measurement of 3D dose distributions. One of the special features of this type of dosimeters is their tissue equivalence, which makes them appropriate for the investigation of dose enhancement with contrast agents with high atomic number. Objective: The purpose of this study is an investigating of dose enhancement dependent in energy within the gel medium with used of conformal distribution gold nanoparticle as contrast agents by high atomic number material. Methods: In this work, gold nanoparticles (GNPs) of 50nm diameter with 0.1m concentration embedded in gel and irradiated by different megavoltage energy of 18MVand 6MV photon beam. Then GN- MAGICA and MAGICA dose response curves compare and achieved dose enhancement. Results: Experimental results have shown dose enhancement factor of 6MV and 18MV in 0.1mM, concentration is 1.74 and 1.04 respectively. Conclusion: The results showed that by adding of gold nanoparticles to the MAGICA polymer gel absorbed dose is increased. The levels of polymerization of irradiated gels with and without AuNPs in energy 6MV is more than energy 18MV. It seems that because of the dominance of photoelectric effect at low energies and pair production effect at high energies.
VL  - 3
IS  - 1
ER  -

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Author Information

Gholamreza Atae

Babol University of Medical Science, paramedical school, Babol, Iran
Seyed Rabee Mahdavi

Iran University of Medical Science, Tehran, Iran
Akram Mohammadi Nokhandani

Babol University of Medical Science, paramedical school, Babol, Iran
Syede Mahsa Taheri Otaghsara

Babol University of Medical Science, paramedical school, Babol, Iran
Mahboubeh Khadem Abolfazli

Babol University of Medical Science, paramedical school, Babol, Iran

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APA Style

Gholamreza Atae, Seyed Rabee Mahdavi, Akram Mohammadi Nokhandani, Syede Mahsa Taheri Otaghsara, Mahboubeh Khadem Abolfazli. (2015). Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter. International Journal of Biomedical Science and Engineering, 3(1), 1-4. https://doi.org/10.11648/j.ijbse.20150301.11

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ACS Style

Gholamreza Atae; Seyed Rabee Mahdavi; Akram Mohammadi Nokhandani; Syede Mahsa Taheri Otaghsara; Mahboubeh Khadem Abolfazli. Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter. Int. J. Biomed. Sci. Eng. 2015, 3(1), 1-4. doi: 10.11648/j.ijbse.20150301.11

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AMA Style

Gholamreza Atae, Seyed Rabee Mahdavi, Akram Mohammadi Nokhandani, Syede Mahsa Taheri Otaghsara, Mahboubeh Khadem Abolfazli. Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter. Int J Biomed Sci Eng. 2015;3(1):1-4. doi: 10.11648/j.ijbse.20150301.11

Copy | Download

@article{10.11648/j.ijbse.20150301.11,
  author = {Gholamreza Atae and Seyed Rabee Mahdavi and Akram Mohammadi Nokhandani and Syede Mahsa Taheri Otaghsara and Mahboubeh Khadem Abolfazli},
  title = {Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {3},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ijbse.20150301.11},
  url = {https://doi.org/10.11648/j.ijbse.20150301.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20150301.11},
  abstract = {Background: Polymer gels beam sensitive are valuable and confident for measurement of 3D dose distributions. One of the special features of this type of dosimeters is their tissue equivalence, which makes them appropriate for the investigation of dose enhancement with contrast agents with high atomic number. Objective: The purpose of this study is an investigating of dose enhancement dependent in energy within the gel medium with used of conformal distribution gold nanoparticle as contrast agents by high atomic number material. Methods: In this work, gold nanoparticles (GNPs) of 50nm diameter with 0.1m concentration embedded in gel and irradiated by different megavoltage energy of 18MVand 6MV photon beam. Then GN- MAGICA and MAGICA dose response curves compare and achieved dose enhancement. Results: Experimental results have shown dose enhancement factor of 6MV and 18MV in 0.1mM, concentration is 1.74 and 1.04 respectively. Conclusion: The results showed that by adding of gold nanoparticles to the MAGICA polymer gel absorbed dose is increased. The levels of polymerization of irradiated gels with and without AuNPs in energy 6MV is more than energy 18MV. It seems that because of the dominance of photoelectric effect at low energies and pair production effect at high energies.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Effect of Mega Voltage Energy on Dose Enhancement in Phantom Study by Using Gold Nanoparticle Polymer Gel Dosimeter
AU  - Gholamreza Atae
AU  - Seyed Rabee Mahdavi
AU  - Akram Mohammadi Nokhandani
AU  - Syede Mahsa Taheri Otaghsara
AU  - Mahboubeh Khadem Abolfazli
Y1  - 2015/01/20
PY  - 2015
N1  - https://doi.org/10.11648/j.ijbse.20150301.11
DO  - 10.11648/j.ijbse.20150301.11
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20150301.11
AB  - Background: Polymer gels beam sensitive are valuable and confident for measurement of 3D dose distributions. One of the special features of this type of dosimeters is their tissue equivalence, which makes them appropriate for the investigation of dose enhancement with contrast agents with high atomic number. Objective: The purpose of this study is an investigating of dose enhancement dependent in energy within the gel medium with used of conformal distribution gold nanoparticle as contrast agents by high atomic number material. Methods: In this work, gold nanoparticles (GNPs) of 50nm diameter with 0.1m concentration embedded in gel and irradiated by different megavoltage energy of 18MVand 6MV photon beam. Then GN- MAGICA and MAGICA dose response curves compare and achieved dose enhancement. Results: Experimental results have shown dose enhancement factor of 6MV and 18MV in 0.1mM, concentration is 1.74 and 1.04 respectively. Conclusion: The results showed that by adding of gold nanoparticles to the MAGICA polymer gel absorbed dose is increased. The levels of polymerization of irradiated gels with and without AuNPs in energy 6MV is more than energy 18MV. It seems that because of the dominance of photoelectric effect at low energies and pair production effect at high energies.
VL  - 3
IS  - 1
ER  -

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