The Risk of Relationship between Hormonal Replacement Therapy and Cancer

Thiele Osvaldt Rosales; Iara Patrícia Albrecht; Guilherme Barroso Langoni de Freitas

doi:doi:10.11648/j.crj.s.2014020601.16

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The Risk of Relationship between Hormonal Replacement Therapy and Cancer

Thiele Osvaldt Rosales, Iara Patrícia Albrecht, Guilherme Barroso Langoni de Freitas

Published in Cancer Research Journal (Volume 2, Issue 6-1)

Received: 10 December 2014 Accepted: 13 December 2014 Published: 27 January 2015

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Abstract

Menopause is an endocrine condition due to the decline in ovarian activity, which occurs in all women and is characterized as a progressive hypoestrogenism. To minimize damage from lack hormonal activity, hormone replacement therapy has been developed (TRH), which is widely used around the world, often without criteria pre-established. Thus, this study aims to identify hormonal therapies used postmenopausal and relate them to the development of tumors. In addition, identify the criteria for the use of HRT, the utilization time and women who are part of the risk groups are also objectives of this study. In the beginning, the clinical methodology of HRT included only estrogen, but epidemiological studies have observed that the progestin presence is essential in endometrial hyperplasia control adding to the therapy. Progestogens act depending on its molecular structure, and consequently selectivity, or may interact with other steroid receptors. From this interaction, different pharmacodynamic answers about importance in the development of tumors can be observed, ie, progesterone activity, estrogen, antiestrogen, androgen and / or antiandrogen. In view of the mechanism of carcinogen administration of estrogens, it can be said that HRT increases the risk of breast, uterus and ovary cancer. However, the estrogenic actions may be adjusted when there is administration of progestin drugs and with antiestrogenic and antiandrogenic actions. Given this, in menopausal women, it is advisable to trace gynecological cancer, before, during and after any therapeutic interventions, and the decision of using and the choice of HRT on an individual basis, through a careful assessment of signs and symptoms and long-term risk.

Published in	Cancer Research Journal (Volume 2, Issue 6-1) This article belongs to the Special Issue Lifestyle and Cancer Risk
DOI	10.11648/j.crj.s.2014020601.16
Page(s)	49-56
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Hormonal replacement therapy, Cancer, Estrogens, Progestogen

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Thiele Osvaldt Rosales, Iara Patrícia Albrecht, Guilherme Barroso Langoni de Freitas. (2015). The Risk of Relationship between Hormonal Replacement Therapy and Cancer. Cancer Research Journal, 2(6-1), 49-56. https://doi.org/10.11648/j.crj.s.2014020601.16

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Thiele Osvaldt Rosales; Iara Patrícia Albrecht; Guilherme Barroso Langoni de Freitas. The Risk of Relationship between Hormonal Replacement Therapy and Cancer. Cancer Res. J. 2015, 2(6-1), 49-56. doi: 10.11648/j.crj.s.2014020601.16

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Thiele Osvaldt Rosales, Iara Patrícia Albrecht, Guilherme Barroso Langoni de Freitas. The Risk of Relationship between Hormonal Replacement Therapy and Cancer. Cancer Res J. 2015;2(6-1):49-56. doi: 10.11648/j.crj.s.2014020601.16

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@article{10.11648/j.crj.s.2014020601.16,
  author = {Thiele Osvaldt Rosales and Iara Patrícia Albrecht and Guilherme Barroso Langoni de Freitas},
  title = {The Risk of Relationship between Hormonal Replacement Therapy and Cancer},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {6-1},
  pages = {49-56},
  doi = {10.11648/j.crj.s.2014020601.16},
  url = {https://doi.org/10.11648/j.crj.s.2014020601.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.s.2014020601.16},
  abstract = {Menopause is an endocrine condition due to the decline in ovarian activity, which occurs in all women and is characterized as a progressive hypoestrogenism. To minimize damage from lack hormonal activity, hormone replacement therapy has been developed (TRH), which is widely used around the world, often without criteria pre-established. Thus, this study aims to identify hormonal therapies used postmenopausal and relate them to the development of tumors. In addition, identify the criteria for the use of HRT, the utilization time and women who are part of the risk groups are also objectives of this study. In the beginning, the clinical methodology of HRT included only estrogen, but epidemiological studies have observed that the progestin presence is essential in endometrial hyperplasia control adding to the therapy. Progestogens act depending on its molecular structure, and consequently selectivity, or may interact with other steroid receptors. From this interaction, different pharmacodynamic answers about importance in the development of tumors can be observed, ie, progesterone activity, estrogen, antiestrogen, androgen and / or antiandrogen. In view of the mechanism of carcinogen administration of estrogens, it can be said that HRT increases the risk of breast, uterus and ovary cancer. However, the estrogenic actions may be adjusted when there is administration of progestin drugs and with antiestrogenic and antiandrogenic actions. Given this, in menopausal women, it is advisable to trace gynecological cancer, before, during and after any therapeutic interventions, and the decision of using and the choice of HRT on an individual basis, through a careful assessment of signs and symptoms and long-term risk.},
 year = {2015}
}

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TY  - JOUR
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AU  - Thiele Osvaldt Rosales
AU  - Iara Patrícia Albrecht
AU  - Guilherme Barroso Langoni de Freitas
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SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.s.2014020601.16
AB  - Menopause is an endocrine condition due to the decline in ovarian activity, which occurs in all women and is characterized as a progressive hypoestrogenism. To minimize damage from lack hormonal activity, hormone replacement therapy has been developed (TRH), which is widely used around the world, often without criteria pre-established. Thus, this study aims to identify hormonal therapies used postmenopausal and relate them to the development of tumors. In addition, identify the criteria for the use of HRT, the utilization time and women who are part of the risk groups are also objectives of this study. In the beginning, the clinical methodology of HRT included only estrogen, but epidemiological studies have observed that the progestin presence is essential in endometrial hyperplasia control adding to the therapy. Progestogens act depending on its molecular structure, and consequently selectivity, or may interact with other steroid receptors. From this interaction, different pharmacodynamic answers about importance in the development of tumors can be observed, ie, progesterone activity, estrogen, antiestrogen, androgen and / or antiandrogen. In view of the mechanism of carcinogen administration of estrogens, it can be said that HRT increases the risk of breast, uterus and ovary cancer. However, the estrogenic actions may be adjusted when there is administration of progestin drugs and with antiestrogenic and antiandrogenic actions. Given this, in menopausal women, it is advisable to trace gynecological cancer, before, during and after any therapeutic interventions, and the decision of using and the choice of HRT on an individual basis, through a careful assessment of signs and symptoms and long-term risk.
VL  - 2
IS  - 6-1
ER  -

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Author Information

Thiele Osvaldt Rosales

Department of Pharmacy, State University of Center-West, Guarapuava, Parana, Brazil
Iara Patrícia Albrecht

Department of Pharmacy, State University of Center-West, Guarapuava, Parana, Brazil
Guilherme Barroso Langoni de Freitas

Department of Pharmacy, State University of Center-West, Guarapuava, Parana, Brazil

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APA Style

Thiele Osvaldt Rosales, Iara Patrícia Albrecht, Guilherme Barroso Langoni de Freitas. (2015). The Risk of Relationship between Hormonal Replacement Therapy and Cancer. Cancer Research Journal, 2(6-1), 49-56. https://doi.org/10.11648/j.crj.s.2014020601.16

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ACS Style

Thiele Osvaldt Rosales; Iara Patrícia Albrecht; Guilherme Barroso Langoni de Freitas. The Risk of Relationship between Hormonal Replacement Therapy and Cancer. Cancer Res. J. 2015, 2(6-1), 49-56. doi: 10.11648/j.crj.s.2014020601.16

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AMA Style

Thiele Osvaldt Rosales, Iara Patrícia Albrecht, Guilherme Barroso Langoni de Freitas. The Risk of Relationship between Hormonal Replacement Therapy and Cancer. Cancer Res J. 2015;2(6-1):49-56. doi: 10.11648/j.crj.s.2014020601.16

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@article{10.11648/j.crj.s.2014020601.16,
  author = {Thiele Osvaldt Rosales and Iara Patrícia Albrecht and Guilherme Barroso Langoni de Freitas},
  title = {The Risk of Relationship between Hormonal Replacement Therapy and Cancer},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {6-1},
  pages = {49-56},
  doi = {10.11648/j.crj.s.2014020601.16},
  url = {https://doi.org/10.11648/j.crj.s.2014020601.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.s.2014020601.16},
  abstract = {Menopause is an endocrine condition due to the decline in ovarian activity, which occurs in all women and is characterized as a progressive hypoestrogenism. To minimize damage from lack hormonal activity, hormone replacement therapy has been developed (TRH), which is widely used around the world, often without criteria pre-established. Thus, this study aims to identify hormonal therapies used postmenopausal and relate them to the development of tumors. In addition, identify the criteria for the use of HRT, the utilization time and women who are part of the risk groups are also objectives of this study. In the beginning, the clinical methodology of HRT included only estrogen, but epidemiological studies have observed that the progestin presence is essential in endometrial hyperplasia control adding to the therapy. Progestogens act depending on its molecular structure, and consequently selectivity, or may interact with other steroid receptors. From this interaction, different pharmacodynamic answers about importance in the development of tumors can be observed, ie, progesterone activity, estrogen, antiestrogen, androgen and / or antiandrogen. In view of the mechanism of carcinogen administration of estrogens, it can be said that HRT increases the risk of breast, uterus and ovary cancer. However, the estrogenic actions may be adjusted when there is administration of progestin drugs and with antiestrogenic and antiandrogenic actions. Given this, in menopausal women, it is advisable to trace gynecological cancer, before, during and after any therapeutic interventions, and the decision of using and the choice of HRT on an individual basis, through a careful assessment of signs and symptoms and long-term risk.},
 year = {2015}
}

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TY  - JOUR
T1  - The Risk of Relationship between Hormonal Replacement Therapy and Cancer
AU  - Thiele Osvaldt Rosales
AU  - Iara Patrícia Albrecht
AU  - Guilherme Barroso Langoni de Freitas
Y1  - 2015/01/27
PY  - 2015
N1  - https://doi.org/10.11648/j.crj.s.2014020601.16
DO  - 10.11648/j.crj.s.2014020601.16
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 49
EP  - 56
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.s.2014020601.16
AB  - Menopause is an endocrine condition due to the decline in ovarian activity, which occurs in all women and is characterized as a progressive hypoestrogenism. To minimize damage from lack hormonal activity, hormone replacement therapy has been developed (TRH), which is widely used around the world, often without criteria pre-established. Thus, this study aims to identify hormonal therapies used postmenopausal and relate them to the development of tumors. In addition, identify the criteria for the use of HRT, the utilization time and women who are part of the risk groups are also objectives of this study. In the beginning, the clinical methodology of HRT included only estrogen, but epidemiological studies have observed that the progestin presence is essential in endometrial hyperplasia control adding to the therapy. Progestogens act depending on its molecular structure, and consequently selectivity, or may interact with other steroid receptors. From this interaction, different pharmacodynamic answers about importance in the development of tumors can be observed, ie, progesterone activity, estrogen, antiestrogen, androgen and / or antiandrogen. In view of the mechanism of carcinogen administration of estrogens, it can be said that HRT increases the risk of breast, uterus and ovary cancer. However, the estrogenic actions may be adjusted when there is administration of progestin drugs and with antiestrogenic and antiandrogenic actions. Given this, in menopausal women, it is advisable to trace gynecological cancer, before, during and after any therapeutic interventions, and the decision of using and the choice of HRT on an individual basis, through a careful assessment of signs and symptoms and long-term risk.
VL  - 2
IS  - 6-1
ER  -

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