Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review

Fernando Seiji Morais; Caio Santos Bonilha; Emerson Carraro

doi:doi:10.11648/j.crj.s.2014020601.11

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Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review

Fernando Seiji Morais, Caio Santos Bonilha, Emerson Carraro

Published in Cancer Research Journal (Volume 2, Issue 6-1)

Received: 21 November 2014 Accepted: 8 December 2014 Published: 27 December 2014

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Abstract

Merkel Cell Polyomavirus (MCV) is a virus belonging to the human Polyomavirus family. After its discovery and detection in approximately 80% of Merkel Cell Carcinoma (MCC) tumors, it has been associated with this rare and aggressive skin cancer that primarily affects elderly and immunosuppressed people. In this study, a systematic review was developed to gather and evidence information about the involvement of MCV infection in the development of MCC. An analysis was performed in the PubMed database in order to find articles to answer the purpose of this present study. Ninety-seven articles met the criteria, forty-six of them investigated the prevalence of MCV in MCC clinical samples, and all showed that the MCV-MCC association exists, with the viral presence ranging from 18 to 100% in MCC tumors. In addition, results pointing to the MCV potential carcinogenic, infection, transmission and replication mechanisms, or even possible disease markers or therapeutic evaluations were found. Current literature has demonstrated frequent involvement of MCV in MCC, with survey of some disease indicative laboratory markers and possible therapeutic evaluations.

Published in	Cancer Research Journal (Volume 2, Issue 6-1) This article belongs to the Special Issue Lifestyle and Cancer Risk
DOI	10.11648/j.crj.s.2014020601.11
Page(s)	1-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Merkel Cell Carcinoma, Merkel Cell Polyomavirus, Carcinogenesis

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Fernando Seiji Morais, Caio Santos Bonilha, Emerson Carraro. (2014). Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review. Cancer Research Journal, 2(6-1), 1-10. https://doi.org/10.11648/j.crj.s.2014020601.11

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Fernando Seiji Morais; Caio Santos Bonilha; Emerson Carraro. Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review. Cancer Res. J. 2014, 2(6-1), 1-10. doi: 10.11648/j.crj.s.2014020601.11

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Fernando Seiji Morais, Caio Santos Bonilha, Emerson Carraro. Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review. Cancer Res J. 2014;2(6-1):1-10. doi: 10.11648/j.crj.s.2014020601.11

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@article{10.11648/j.crj.s.2014020601.11,
  author = {Fernando Seiji Morais and Caio Santos Bonilha and Emerson Carraro},
  title = {Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {6-1},
  pages = {1-10},
  doi = {10.11648/j.crj.s.2014020601.11},
  url = {https://doi.org/10.11648/j.crj.s.2014020601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.s.2014020601.11},
  abstract = {Merkel Cell Polyomavirus (MCV) is a virus belonging to the human Polyomavirus family. After its discovery and detection in approximately 80% of Merkel Cell Carcinoma (MCC) tumors, it has been associated with this rare and aggressive skin cancer that primarily affects elderly and immunosuppressed people. In this study, a systematic review was developed to gather and evidence information about the involvement of MCV infection in the development of MCC. An analysis was performed in the PubMed database in order to find articles to answer the purpose of this present study. Ninety-seven articles met the criteria, forty-six of them investigated the prevalence of MCV in MCC clinical samples, and all showed that the MCV-MCC association exists, with the viral presence ranging from 18 to 100% in MCC tumors. In addition, results pointing to the MCV potential carcinogenic, infection, transmission and replication mechanisms, or even possible disease markers or therapeutic evaluations were found. Current literature has demonstrated frequent involvement of MCV in MCC, with survey of some disease indicative laboratory markers and possible therapeutic evaluations.},
 year = {2014}
}

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TY  - JOUR
T1  - Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review
AU  - Fernando Seiji Morais
AU  - Caio Santos Bonilha
AU  - Emerson Carraro
Y1  - 2014/12/27
PY  - 2014
N1  - https://doi.org/10.11648/j.crj.s.2014020601.11
DO  - 10.11648/j.crj.s.2014020601.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 1
EP  - 10
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.s.2014020601.11
AB  - Merkel Cell Polyomavirus (MCV) is a virus belonging to the human Polyomavirus family. After its discovery and detection in approximately 80% of Merkel Cell Carcinoma (MCC) tumors, it has been associated with this rare and aggressive skin cancer that primarily affects elderly and immunosuppressed people. In this study, a systematic review was developed to gather and evidence information about the involvement of MCV infection in the development of MCC. An analysis was performed in the PubMed database in order to find articles to answer the purpose of this present study. Ninety-seven articles met the criteria, forty-six of them investigated the prevalence of MCV in MCC clinical samples, and all showed that the MCV-MCC association exists, with the viral presence ranging from 18 to 100% in MCC tumors. In addition, results pointing to the MCV potential carcinogenic, infection, transmission and replication mechanisms, or even possible disease markers or therapeutic evaluations were found. Current literature has demonstrated frequent involvement of MCV in MCC, with survey of some disease indicative laboratory markers and possible therapeutic evaluations.
VL  - 2
IS  - 6-1
ER  -

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Author Information

Fernando Seiji Morais

Pharmacy Department, Masters Program in Pharmaceutical Sciences, Universidade Estadual do Centro-Oeste (State University of Center-West) (UNICENTRO), Guarapuava-PR, Brazil
Caio Santos Bonilha

Pharmacy Department, Masters Program in Pharmaceutical Sciences, Universidade Estadual do Centro-Oeste (State University of Center-West) (UNICENTRO), Guarapuava-PR, Brazil
Emerson Carraro

Pharmacy Department, Masters Program in Pharmaceutical Sciences, Universidade Estadual do Centro-Oeste (State University of Center-West) (UNICENTRO), Guarapuava-PR, Brazil

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APA Style

Fernando Seiji Morais, Caio Santos Bonilha, Emerson Carraro. (2014). Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review. Cancer Research Journal, 2(6-1), 1-10. https://doi.org/10.11648/j.crj.s.2014020601.11

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ACS Style

Fernando Seiji Morais; Caio Santos Bonilha; Emerson Carraro. Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review. Cancer Res. J. 2014, 2(6-1), 1-10. doi: 10.11648/j.crj.s.2014020601.11

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AMA Style

Fernando Seiji Morais, Caio Santos Bonilha, Emerson Carraro. Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review. Cancer Res J. 2014;2(6-1):1-10. doi: 10.11648/j.crj.s.2014020601.11

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@article{10.11648/j.crj.s.2014020601.11,
  author = {Fernando Seiji Morais and Caio Santos Bonilha and Emerson Carraro},
  title = {Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {6-1},
  pages = {1-10},
  doi = {10.11648/j.crj.s.2014020601.11},
  url = {https://doi.org/10.11648/j.crj.s.2014020601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.s.2014020601.11},
  abstract = {Merkel Cell Polyomavirus (MCV) is a virus belonging to the human Polyomavirus family. After its discovery and detection in approximately 80% of Merkel Cell Carcinoma (MCC) tumors, it has been associated with this rare and aggressive skin cancer that primarily affects elderly and immunosuppressed people. In this study, a systematic review was developed to gather and evidence information about the involvement of MCV infection in the development of MCC. An analysis was performed in the PubMed database in order to find articles to answer the purpose of this present study. Ninety-seven articles met the criteria, forty-six of them investigated the prevalence of MCV in MCC clinical samples, and all showed that the MCV-MCC association exists, with the viral presence ranging from 18 to 100% in MCC tumors. In addition, results pointing to the MCV potential carcinogenic, infection, transmission and replication mechanisms, or even possible disease markers or therapeutic evaluations were found. Current literature has demonstrated frequent involvement of MCV in MCC, with survey of some disease indicative laboratory markers and possible therapeutic evaluations.},
 year = {2014}
}

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TY  - JOUR
T1  - Involvement of Merkel Cell Polyomavirus in the Etiology and Pathogenesis of Merkel Cell Carcinoma: A Systematic Review
AU  - Fernando Seiji Morais
AU  - Caio Santos Bonilha
AU  - Emerson Carraro
Y1  - 2014/12/27
PY  - 2014
N1  - https://doi.org/10.11648/j.crj.s.2014020601.11
DO  - 10.11648/j.crj.s.2014020601.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 1
EP  - 10
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.s.2014020601.11
AB  - Merkel Cell Polyomavirus (MCV) is a virus belonging to the human Polyomavirus family. After its discovery and detection in approximately 80% of Merkel Cell Carcinoma (MCC) tumors, it has been associated with this rare and aggressive skin cancer that primarily affects elderly and immunosuppressed people. In this study, a systematic review was developed to gather and evidence information about the involvement of MCV infection in the development of MCC. An analysis was performed in the PubMed database in order to find articles to answer the purpose of this present study. Ninety-seven articles met the criteria, forty-six of them investigated the prevalence of MCV in MCC clinical samples, and all showed that the MCV-MCC association exists, with the viral presence ranging from 18 to 100% in MCC tumors. In addition, results pointing to the MCV potential carcinogenic, infection, transmission and replication mechanisms, or even possible disease markers or therapeutic evaluations were found. Current literature has demonstrated frequent involvement of MCV in MCC, with survey of some disease indicative laboratory markers and possible therapeutic evaluations.
VL  - 2
IS  - 6-1
ER  -

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