Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature

Georgewill Udeme Owunari; Siminialayi Iyeopu Minakiri

doi:doi:10.11648/j.crj.20140205.12

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Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature

Georgewill Udeme Owunari, Siminialayi Iyeopu Minakiri

Published in Cancer Research Journal (Volume 2, Issue 5)

Received: 2 September 2014 Accepted: 16 September 2014 Published: 30 September 2014

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Abstract

Repurposing non- cancer related drugs with possible antitumoral activities is a promising strategy for identifying prospective new anticancer drugs in a cost efficient and time saving way. Repurposing disulfiram has recently become of interest because of its pre-clinically described anticancer effects against various human cancers, which include breast, cervical, colorectal, lung, melanoma, prostate as well as myeloma and leukaemia. Epidemiological studies reveal a trend to reduced cancer risks in cancer patients using disulfiram for chronic alcoholism treatment while already reported literature point to the efficacy of disulfiram on cancer cell lines. Disulfiram has been shown to be effective either as a stand alone or in combination with other drugs against metastatic liver cancer, lung cancer, prostate cancer, glioblastoma and melanoma. Preclinical studies indicate that disulfiram when combined with copper ions acts as a proteasome inhibitor, to induce oxidative stress, reduce NFƙB (Nuclear factor ƙappa Binding) activity and enhance the sensitivity of cancer cells to chemotherapeutic agents. This study analyzed existing literature and found that disulfiram in combination with copper gluconate is a promising therapeutic agent for use in cancer chemotherapy.

Published in	Cancer Research Journal (Volume 2, Issue 5)
DOI	10.11648/j.crj.20140205.12
Page(s)	88-92
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Cancer, Disulfiram, Copper gluconate

References

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APA Style

Georgewill Udeme Owunari, Siminialayi Iyeopu Minakiri. (2014). Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature. Cancer Research Journal, 2(5), 88-92. https://doi.org/10.11648/j.crj.20140205.12

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ACS Style

Georgewill Udeme Owunari; Siminialayi Iyeopu Minakiri. Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature. Cancer Res. J. 2014, 2(5), 88-92. doi: 10.11648/j.crj.20140205.12

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AMA Style

Georgewill Udeme Owunari, Siminialayi Iyeopu Minakiri. Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature. Cancer Res J. 2014;2(5):88-92. doi: 10.11648/j.crj.20140205.12

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@article{10.11648/j.crj.20140205.12,
  author = {Georgewill Udeme Owunari and Siminialayi Iyeopu Minakiri},
  title = {Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {5},
  pages = {88-92},
  doi = {10.11648/j.crj.20140205.12},
  url = {https://doi.org/10.11648/j.crj.20140205.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20140205.12},
  abstract = {Repurposing non- cancer related drugs with possible antitumoral activities is a promising strategy for  identifying prospective new anticancer drugs in a cost efficient and time saving way. Repurposing disulfiram has recently become of interest because of its pre-clinically described anticancer effects against various human cancers, which include breast, cervical, colorectal, lung, melanoma, prostate as well as myeloma and leukaemia. Epidemiological studies reveal a trend to reduced cancer risks in cancer patients using disulfiram for chronic alcoholism treatment while already reported literature  point to the efficacy of disulfiram on cancer cell lines. Disulfiram has been shown to be effective either as a stand alone or in combination with other drugs against metastatic liver cancer, lung cancer, prostate cancer, glioblastoma and melanoma. Preclinical studies indicate that disulfiram when combined with copper ions acts as a proteasome inhibitor, to induce oxidative stress, reduce NFƙB (Nuclear factor ƙappa Binding) activity and enhance the sensitivity of cancer cells to chemotherapeutic agents. This study analyzed existing literature and found that disulfiram in combination with copper gluconate is a promising therapeutic  agent for use in cancer chemotherapy.},
 year = {2014}
}

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TY  - JOUR
T1  - Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature
AU  - Georgewill Udeme Owunari
AU  - Siminialayi Iyeopu Minakiri
Y1  - 2014/09/30
PY  - 2014
N1  - https://doi.org/10.11648/j.crj.20140205.12
DO  - 10.11648/j.crj.20140205.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
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EP  - 92
PB  - Science Publishing Group
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AB  - Repurposing non- cancer related drugs with possible antitumoral activities is a promising strategy for  identifying prospective new anticancer drugs in a cost efficient and time saving way. Repurposing disulfiram has recently become of interest because of its pre-clinically described anticancer effects against various human cancers, which include breast, cervical, colorectal, lung, melanoma, prostate as well as myeloma and leukaemia. Epidemiological studies reveal a trend to reduced cancer risks in cancer patients using disulfiram for chronic alcoholism treatment while already reported literature  point to the efficacy of disulfiram on cancer cell lines. Disulfiram has been shown to be effective either as a stand alone or in combination with other drugs against metastatic liver cancer, lung cancer, prostate cancer, glioblastoma and melanoma. Preclinical studies indicate that disulfiram when combined with copper ions acts as a proteasome inhibitor, to induce oxidative stress, reduce NFƙB (Nuclear factor ƙappa Binding) activity and enhance the sensitivity of cancer cells to chemotherapeutic agents. This study analyzed existing literature and found that disulfiram in combination with copper gluconate is a promising therapeutic  agent for use in cancer chemotherapy.
VL  - 2
IS  - 5
ER  -

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Author Information

Georgewill Udeme Owunari

Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria
Siminialayi Iyeopu Minakiri

Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria

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Plain Text BibTeX RIS

APA Style

Georgewill Udeme Owunari, Siminialayi Iyeopu Minakiri. (2014). Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature. Cancer Research Journal, 2(5), 88-92. https://doi.org/10.11648/j.crj.20140205.12

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ACS Style

Georgewill Udeme Owunari; Siminialayi Iyeopu Minakiri. Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature. Cancer Res. J. 2014, 2(5), 88-92. doi: 10.11648/j.crj.20140205.12

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AMA Style

Georgewill Udeme Owunari, Siminialayi Iyeopu Minakiri. Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature. Cancer Res J. 2014;2(5):88-92. doi: 10.11648/j.crj.20140205.12

Copy | Download

@article{10.11648/j.crj.20140205.12,
  author = {Georgewill Udeme Owunari and Siminialayi Iyeopu Minakiri},
  title = {Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature},
  journal = {Cancer Research Journal},
  volume = {2},
  number = {5},
  pages = {88-92},
  doi = {10.11648/j.crj.20140205.12},
  url = {https://doi.org/10.11648/j.crj.20140205.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20140205.12},
  abstract = {Repurposing non- cancer related drugs with possible antitumoral activities is a promising strategy for  identifying prospective new anticancer drugs in a cost efficient and time saving way. Repurposing disulfiram has recently become of interest because of its pre-clinically described anticancer effects against various human cancers, which include breast, cervical, colorectal, lung, melanoma, prostate as well as myeloma and leukaemia. Epidemiological studies reveal a trend to reduced cancer risks in cancer patients using disulfiram for chronic alcoholism treatment while already reported literature  point to the efficacy of disulfiram on cancer cell lines. Disulfiram has been shown to be effective either as a stand alone or in combination with other drugs against metastatic liver cancer, lung cancer, prostate cancer, glioblastoma and melanoma. Preclinical studies indicate that disulfiram when combined with copper ions acts as a proteasome inhibitor, to induce oxidative stress, reduce NFƙB (Nuclear factor ƙappa Binding) activity and enhance the sensitivity of cancer cells to chemotherapeutic agents. This study analyzed existing literature and found that disulfiram in combination with copper gluconate is a promising therapeutic  agent for use in cancer chemotherapy.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Disulfiram and Copper Gluconate in Cancer Chemotherapy; a Review of the Literature
AU  - Georgewill Udeme Owunari
AU  - Siminialayi Iyeopu Minakiri
Y1  - 2014/09/30
PY  - 2014
N1  - https://doi.org/10.11648/j.crj.20140205.12
DO  - 10.11648/j.crj.20140205.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 88
EP  - 92
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20140205.12
AB  - Repurposing non- cancer related drugs with possible antitumoral activities is a promising strategy for  identifying prospective new anticancer drugs in a cost efficient and time saving way. Repurposing disulfiram has recently become of interest because of its pre-clinically described anticancer effects against various human cancers, which include breast, cervical, colorectal, lung, melanoma, prostate as well as myeloma and leukaemia. Epidemiological studies reveal a trend to reduced cancer risks in cancer patients using disulfiram for chronic alcoholism treatment while already reported literature  point to the efficacy of disulfiram on cancer cell lines. Disulfiram has been shown to be effective either as a stand alone or in combination with other drugs against metastatic liver cancer, lung cancer, prostate cancer, glioblastoma and melanoma. Preclinical studies indicate that disulfiram when combined with copper ions acts as a proteasome inhibitor, to induce oxidative stress, reduce NFƙB (Nuclear factor ƙappa Binding) activity and enhance the sensitivity of cancer cells to chemotherapeutic agents. This study analyzed existing literature and found that disulfiram in combination with copper gluconate is a promising therapeutic  agent for use in cancer chemotherapy.
VL  - 2
IS  - 5
ER  -

Copy | Download