Angiogenesis is the extension of blood vessels from the prevailing vessels. It is an essential process in the formation and development of blood vessels, so it is supportive in healing of wound while its inhibition may help to restrict the size of tumor. To quantify the effect of an agent on angiogenesis, a standardized preclinical screening assay is necessary. The objective of this review is to document all the methods of angiogenesis assessment and specific techniques to quantify the results, majorly focusing on the modes of calculation and concerns that researchers need to make before reaching to any conclusion. Scientific research on angiogenesis relies on different models for assessment, including in vitro, in vivo and in ovo models. Many of these assays are practiced to test the effect of both pro and anti angiogenic agents. The findings articulated in this study will help to provide better visions into the pathophysiology of diseases associated with angiogenesis and to establish new as well as appropriate angiogenic or anti angiogenic treatment strategies for the future. Nevertheless, angiogenesis is a vigorous process and the techniques to evaluate this process with thorough assessment of physiological characteristics of new blood vessels will be advantageous over the older systems of angiogenesis assessment methods.
| Published in | Cancer Research Journal (Volume 2, Issue 3) |
| DOI | 10.11648/j.crj.20140203.12 |
| Page(s) | 47-62 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Angiogenesis, Angiogenesis Assays, Anti-Angiogenic, Quantification Techniques, In vitro, In vivo, Inovo, Treatment Strategies, Blood Vessels, Healing, Non-Invasive
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APA Style
Ghulam Jilany Khan, Lubna Shakir, Sara Khan, H. Sadaf Naeem, Muhammad Ovais Omer. (2014). Assessment Methods of Angiogenesis and Present Approaches for Its Quantification. Cancer Research Journal, 2(3), 47-62. https://doi.org/10.11648/j.crj.20140203.12
ACS Style
Ghulam Jilany Khan; Lubna Shakir; Sara Khan; H. Sadaf Naeem; Muhammad Ovais Omer. Assessment Methods of Angiogenesis and Present Approaches for Its Quantification. Cancer Res. J. 2014, 2(3), 47-62. doi: 10.11648/j.crj.20140203.12
AMA Style
Ghulam Jilany Khan, Lubna Shakir, Sara Khan, H. Sadaf Naeem, Muhammad Ovais Omer. Assessment Methods of Angiogenesis and Present Approaches for Its Quantification. Cancer Res J. 2014;2(3):47-62. doi: 10.11648/j.crj.20140203.12
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Download@article{10.11648/j.crj.20140203.12,
author = {Ghulam Jilany Khan and Lubna Shakir and Sara Khan and H. Sadaf Naeem and Muhammad Ovais Omer},
title = {Assessment Methods of Angiogenesis and Present Approaches for Its Quantification},
journal = {Cancer Research Journal},
volume = {2},
number = {3},
pages = {47-62},
doi = {10.11648/j.crj.20140203.12},
url = {https://doi.org/10.11648/j.crj.20140203.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20140203.12},
abstract = {Angiogenesis is the extension of blood vessels from the prevailing vessels. It is an essential process in the formation and development of blood vessels, so it is supportive in healing of wound while its inhibition may help to restrict the size of tumor. To quantify the effect of an agent on angiogenesis, a standardized preclinical screening assay is necessary. The objective of this review is to document all the methods of angiogenesis assessment and specific techniques to quantify the results, majorly focusing on the modes of calculation and concerns that researchers need to make before reaching to any conclusion. Scientific research on angiogenesis relies on different models for assessment, including in vitro, in vivo and in ovo models. Many of these assays are practiced to test the effect of both pro and anti angiogenic agents. The findings articulated in this study will help to provide better visions into the pathophysiology of diseases associated with angiogenesis and to establish new as well as appropriate angiogenic or anti angiogenic treatment strategies for the future. Nevertheless, angiogenesis is a vigorous process and the techniques to evaluate this process with thorough assessment of physiological characteristics of new blood vessels will be advantageous over the older systems of angiogenesis assessment methods.},
year = {2014}
}
TY - JOUR T1 - Assessment Methods of Angiogenesis and Present Approaches for Its Quantification AU - Ghulam Jilany Khan AU - Lubna Shakir AU - Sara Khan AU - H. Sadaf Naeem AU - Muhammad Ovais Omer Y1 - 2014/06/30 PY - 2014 N1 - https://doi.org/10.11648/j.crj.20140203.12 DO - 10.11648/j.crj.20140203.12 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 47 EP - 62 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20140203.12 AB - Angiogenesis is the extension of blood vessels from the prevailing vessels. It is an essential process in the formation and development of blood vessels, so it is supportive in healing of wound while its inhibition may help to restrict the size of tumor. To quantify the effect of an agent on angiogenesis, a standardized preclinical screening assay is necessary. The objective of this review is to document all the methods of angiogenesis assessment and specific techniques to quantify the results, majorly focusing on the modes of calculation and concerns that researchers need to make before reaching to any conclusion. Scientific research on angiogenesis relies on different models for assessment, including in vitro, in vivo and in ovo models. Many of these assays are practiced to test the effect of both pro and anti angiogenic agents. The findings articulated in this study will help to provide better visions into the pathophysiology of diseases associated with angiogenesis and to establish new as well as appropriate angiogenic or anti angiogenic treatment strategies for the future. Nevertheless, angiogenesis is a vigorous process and the techniques to evaluate this process with thorough assessment of physiological characteristics of new blood vessels will be advantageous over the older systems of angiogenesis assessment methods. VL - 2 IS - 3 ER -
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