Background: Infant mortality rate (IMR) was found to increase in the newborn. The most frequent causes of death are infection, prematurity, low birth weight (LBW), neonatal asphyxia and birth trauma, respectively. Absolute neutrophil count (ANC) can be used as a marker of infection because of its faster, easier, simpler and cheaper nature. Objective: The study aims to identify the influence of an increase and decline in ANC on newborns from mothers with risk factors for early onset sepsis. Methods: This study was conducted as a a prospective cohort study from December 2013 to July 2014. The population included 120 newborns whose mother has risk factors of early onset sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital, and joined hospital. The subjects were divided into three groups, ANC <1800/mm3, ANC 1800-5399/mm3 and ANC >5400/mm3. Results: Newborn from mother with risk factor of infection with ANC >5400/mm3 and ANC 1800-5399/mm3 shows a significant difference with p = 0.000 (p<0.001); OR 8.143; IK 95% 2.440-27.173. Cut off point of 10.710-10890/mm3 was found from ROC analyses in ANC >5400/mm3 group with sensitivity and specificity 89.47% and 80.95% respectively; PPV (Positive predictive value) 80.95%; NPV (Negative predictive value) 89.47%; p=0.000; OR 36.125; IC 95% 5.820 – 224.224. Conclusions: Absolute neutrophil count >10.710/mm3 in a term newborn from mother with infection risk factors can be used as predictor for early onset sepsis 36 fold higher than the ANC <10.710/mm3.
| Published in | Clinical Medicine Research (Volume 4, Issue 3) |
| DOI | 10.11648/j.cmr.20150403.15 |
| Page(s) | 87-91 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Early Onset Sepsis, Absolute Neutrophil Count, Predictor Factor
| [1] | Sudarianto., Mursalim., Nur, M., Syahrir., Nurmiyati., Haruna, I., et al. Health profile of South Sulawesi 2008. Public Health Office of South Sulawesi. 2009; (1) |
| [2] | Alamsyah, Effek. Epidemiological analysis of neonatal maternal health efforts in Indonesia in achieving the target of millenium development goals (mdgs) 2015. Buletin Perinasia. 2010; (1) |
| [3] | Burgner, D., Strunk, T. Genetic Susceptibility to Neonatal Infection. Department of Neonatal Paediatrics. Australia. 2006; 19 (3): 259-63. |
| [4] | Schmutz, N., Henry, E., Jopling, J., Christensen, D. Expected ranges for blood neutrophil concentrations of neonates: The Manroe and Mouzinho charts revisited. J Perinatol. 2008; 28 (4): 275-81. |
| [5] | Bhandari, V., Wang, C., Rinder, C., Rinder, H. Hematologic profile of sepsis in neonates: neutrophil cd64 as a diagnostic marker. Pediatrics. 2008; 121: 129. |
| [6] | Bellig, L., Ohning, B. Neonatal sepsis. http://emedicine.medscape.com/article/978352-overview. 2014 |
| [7] | Anwer, K., Mustafa, S. Rapid identification of neonatal sepsis. Journal of Pakistan Medical Association. 2000. |
| [8] | Health Ministry of Indonesia. Management of Sepsis Neonatorum. 2007. |
| [9] | Dzwonek AB., Neth OW., Thiebaut R., Gulczynska E., Chilton M., Hellwig T. The role of mannose-binding lectin in susceptibility to infection in preterm neonates. Pediatric Research. 2008; 63: 680-85. |
| [10] | Frakking, F.N.J., Brouwer, N., Eijkelenburg, N.K.A. Van, Merkus, M.P., Kuijpers, T.W., et al. Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis. British society for immunology, Clinical and Experimental Immunology. 2007; 150: 255-62. |
| [11] | Schlapbach L.J., Mattmann M., Thiel S., Boillat C., Otth M., Nelle M., et al. Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsis. 2010; 1058-4838/2010/5102-0006. |
| [12] | Mohamed, W. A. Wahab., Saeed, M. A. Mannose-binding lectin serum levels in neonatal sepsis and septic shock. Journal of Maternal-Fetal and Neonatal Medicine. 2012; 25 (4): 411–414. |
APA Style
Hijrah Harmansyah, Ema Alasiry, Dasril Daud. (2015). Absolute Neutrophil Count as Predictor of Early Onset Sepsis. Clinical Medicine Research, 4(3), 87-91. https://doi.org/10.11648/j.cmr.20150403.15
ACS Style
Hijrah Harmansyah; Ema Alasiry; Dasril Daud. Absolute Neutrophil Count as Predictor of Early Onset Sepsis. Clin. Med. Res. 2015, 4(3), 87-91. doi: 10.11648/j.cmr.20150403.15
AMA Style
Hijrah Harmansyah, Ema Alasiry, Dasril Daud. Absolute Neutrophil Count as Predictor of Early Onset Sepsis. Clin Med Res. 2015;4(3):87-91. doi: 10.11648/j.cmr.20150403.15
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.cmr.20150403.15,
author = {Hijrah Harmansyah and Ema Alasiry and Dasril Daud},
title = {Absolute Neutrophil Count as Predictor of Early Onset Sepsis},
journal = {Clinical Medicine Research},
volume = {4},
number = {3},
pages = {87-91},
doi = {10.11648/j.cmr.20150403.15},
url = {https://doi.org/10.11648/j.cmr.20150403.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20150403.15},
abstract = {Background: Infant mortality rate (IMR) was found to increase in the newborn. The most frequent causes of death are infection, prematurity, low birth weight (LBW), neonatal asphyxia and birth trauma, respectively. Absolute neutrophil count (ANC) can be used as a marker of infection because of its faster, easier, simpler and cheaper nature. Objective: The study aims to identify the influence of an increase and decline in ANC on newborns from mothers with risk factors for early onset sepsis. Methods: This study was conducted as a a prospective cohort study from December 2013 to July 2014. The population included 120 newborns whose mother has risk factors of early onset sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital, and joined hospital. The subjects were divided into three groups, ANC 5400/mm3. Results: Newborn from mother with risk factor of infection with ANC >5400/mm3 and ANC 1800-5399/mm3 shows a significant difference with p = 0.000 (p5400/mm3 group with sensitivity and specificity 89.47% and 80.95% respectively; PPV (Positive predictive value) 80.95%; NPV (Negative predictive value) 89.47%; p=0.000; OR 36.125; IC 95% 5.820 – 224.224. Conclusions: Absolute neutrophil count >10.710/mm3 in a term newborn from mother with infection risk factors can be used as predictor for early onset sepsis 36 fold higher than the ANC <10.710/mm3.},
year = {2015}
}
TY - JOUR T1 - Absolute Neutrophil Count as Predictor of Early Onset Sepsis AU - Hijrah Harmansyah AU - Ema Alasiry AU - Dasril Daud Y1 - 2015/05/19 PY - 2015 N1 - https://doi.org/10.11648/j.cmr.20150403.15 DO - 10.11648/j.cmr.20150403.15 T2 - Clinical Medicine Research JF - Clinical Medicine Research JO - Clinical Medicine Research SP - 87 EP - 91 PB - Science Publishing Group SN - 2326-9057 UR - https://doi.org/10.11648/j.cmr.20150403.15 AB - Background: Infant mortality rate (IMR) was found to increase in the newborn. The most frequent causes of death are infection, prematurity, low birth weight (LBW), neonatal asphyxia and birth trauma, respectively. Absolute neutrophil count (ANC) can be used as a marker of infection because of its faster, easier, simpler and cheaper nature. Objective: The study aims to identify the influence of an increase and decline in ANC on newborns from mothers with risk factors for early onset sepsis. Methods: This study was conducted as a a prospective cohort study from December 2013 to July 2014. The population included 120 newborns whose mother has risk factors of early onset sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital, and joined hospital. The subjects were divided into three groups, ANC 5400/mm3. Results: Newborn from mother with risk factor of infection with ANC >5400/mm3 and ANC 1800-5399/mm3 shows a significant difference with p = 0.000 (p5400/mm3 group with sensitivity and specificity 89.47% and 80.95% respectively; PPV (Positive predictive value) 80.95%; NPV (Negative predictive value) 89.47%; p=0.000; OR 36.125; IC 95% 5.820 – 224.224. Conclusions: Absolute neutrophil count >10.710/mm3 in a term newborn from mother with infection risk factors can be used as predictor for early onset sepsis 36 fold higher than the ANC <10.710/mm3. VL - 4 IS - 3 ER -
Email: