In recent years we have witnessed mounting evidences on how a normal cell changes its cellular signaling and metabolic pathways to become highly proliferative cancer cell. Since mitochondrion is a major hub of energy production and several metabolic pathways, it is taking the center stage in defining alterations in energy homeostasis and metabolic rerouting of cancer cell proliferation. Similarly, mutations in the mitochondrial genome in cancer are providing new insights on how these mutations affect mitochondrial functions and change the oncogenic signaling and apoptosis mechanism. In this review, we will summarize these important mitochondrial mechanisms that contribute significantly in the progression of cancer. Further therapeutic approaches targeted to these altered mitochondrial mechanism in cancer are discussed. This review is a part of special issue on Mitochondria: implications in human health and diseases.
| Published in |
Cell Biology (Volume 3, Issue 2-1)
This article belongs to the Special Issue Mitochondria: Implications in Human Health and Diseases |
| DOI | 10.11648/j.cb.s.2015030201.12 |
| Page(s) | 8-16 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Mitochondria, Metabolism, Reactive Oxygen Species and Cancer
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APA Style
Lokendra Kumar Sharma, Meenakshi Tiwari, Santosh Kumar Mishra. (2015). Mitochondrial Alteration: A Major Player in Carcinogenesis. Cell Biology, 3(2-1), 8-16. https://doi.org/10.11648/j.cb.s.2015030201.12
ACS Style
Lokendra Kumar Sharma; Meenakshi Tiwari; Santosh Kumar Mishra. Mitochondrial Alteration: A Major Player in Carcinogenesis. Cell Biol. 2015, 3(2-1), 8-16. doi: 10.11648/j.cb.s.2015030201.12
AMA Style
Lokendra Kumar Sharma, Meenakshi Tiwari, Santosh Kumar Mishra. Mitochondrial Alteration: A Major Player in Carcinogenesis. Cell Biol. 2015;3(2-1):8-16. doi: 10.11648/j.cb.s.2015030201.12
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Download@article{10.11648/j.cb.s.2015030201.12,
author = {Lokendra Kumar Sharma and Meenakshi Tiwari and Santosh Kumar Mishra},
title = {Mitochondrial Alteration: A Major Player in Carcinogenesis},
journal = {Cell Biology},
volume = {3},
number = {2-1},
pages = {8-16},
doi = {10.11648/j.cb.s.2015030201.12},
url = {https://doi.org/10.11648/j.cb.s.2015030201.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.s.2015030201.12},
abstract = {In recent years we have witnessed mounting evidences on how a normal cell changes its cellular signaling and metabolic pathways to become highly proliferative cancer cell. Since mitochondrion is a major hub of energy production and several metabolic pathways, it is taking the center stage in defining alterations in energy homeostasis and metabolic rerouting of cancer cell proliferation. Similarly, mutations in the mitochondrial genome in cancer are providing new insights on how these mutations affect mitochondrial functions and change the oncogenic signaling and apoptosis mechanism. In this review, we will summarize these important mitochondrial mechanisms that contribute significantly in the progression of cancer. Further therapeutic approaches targeted to these altered mitochondrial mechanism in cancer are discussed. This review is a part of special issue on Mitochondria: implications in human health and diseases.},
year = {2015}
}
TY - JOUR T1 - Mitochondrial Alteration: A Major Player in Carcinogenesis AU - Lokendra Kumar Sharma AU - Meenakshi Tiwari AU - Santosh Kumar Mishra Y1 - 2015/02/10 PY - 2015 N1 - https://doi.org/10.11648/j.cb.s.2015030201.12 DO - 10.11648/j.cb.s.2015030201.12 T2 - Cell Biology JF - Cell Biology JO - Cell Biology SP - 8 EP - 16 PB - Science Publishing Group SN - 2330-0183 UR - https://doi.org/10.11648/j.cb.s.2015030201.12 AB - In recent years we have witnessed mounting evidences on how a normal cell changes its cellular signaling and metabolic pathways to become highly proliferative cancer cell. Since mitochondrion is a major hub of energy production and several metabolic pathways, it is taking the center stage in defining alterations in energy homeostasis and metabolic rerouting of cancer cell proliferation. Similarly, mutations in the mitochondrial genome in cancer are providing new insights on how these mutations affect mitochondrial functions and change the oncogenic signaling and apoptosis mechanism. In this review, we will summarize these important mitochondrial mechanisms that contribute significantly in the progression of cancer. Further therapeutic approaches targeted to these altered mitochondrial mechanism in cancer are discussed. This review is a part of special issue on Mitochondria: implications in human health and diseases. VL - 3 IS - 2-1 ER -
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