Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits

Jimoh A.; Tanko Y.; Ahmed A.; Mohammed A.; Ayo J. O.

doi:doi:10.11648/j.cb.20150301.13

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Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits

Jimoh A., Tanko Y., Ahmed A., Mohammed A., Ayo J. O.

Published in Cell Biology (Volume 3, Issue 1)

Received: 15 January 2015 Accepted: 22 January 2015 Published: 2 February 2015

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Abstract

Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P < 0.05) decrease in blood glucose level in HFD group treated with resveratrol compared with HFD group only after 5 weeks of the experimental protocol. Significant (P < 0.05) decrease in T3 and T4 levels were also observed in HFD group compared to the control group. Slight increase in T3 level was observed in HFD group treated with resveratrol but not significant (P > 0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.

Published in	Cell Biology (Volume 3, Issue 1)
DOI	10.11648/j.cb.20150301.13
Page(s)	19-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

High Fat Diet, Blood Glucose Level, Rabbit, Thyroid Hormone

References

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Jimoh A., Tanko Y., Ahmed A., Mohammed A., Ayo J. O. (2015). Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits. Cell Biology, 3(1), 19-24. https://doi.org/10.11648/j.cb.20150301.13

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ACS Style

Jimoh A.; Tanko Y.; Ahmed A.; Mohammed A.; Ayo J. O. Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits. Cell Biol. 2015, 3(1), 19-24. doi: 10.11648/j.cb.20150301.13

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AMA Style

Jimoh A., Tanko Y., Ahmed A., Mohammed A., Ayo J. O. Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits. Cell Biol. 2015;3(1):19-24. doi: 10.11648/j.cb.20150301.13

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@article{10.11648/j.cb.20150301.13,
  author = {Jimoh A. and Tanko Y. and Ahmed A. and Mohammed A. and Ayo J. O.},
  title = {Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits},
  journal = {Cell Biology},
  volume = {3},
  number = {1},
  pages = {19-24},
  doi = {10.11648/j.cb.20150301.13},
  url = {https://doi.org/10.11648/j.cb.20150301.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20150301.13},
  abstract = {Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P  0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.},
 year = {2015}
}

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TY  - JOUR
T1  - Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits
AU  - Jimoh A.
AU  - Tanko Y.
AU  - Ahmed A.
AU  - Mohammed A.
AU  - Ayo J. O.
Y1  - 2015/02/02
PY  - 2015
N1  - https://doi.org/10.11648/j.cb.20150301.13
DO  - 10.11648/j.cb.20150301.13
T2  - Cell Biology
JF  - Cell Biology
JO  - Cell Biology
SP  - 19
EP  - 24
PB  - Science Publishing Group
SN  - 2330-0183
UR  - https://doi.org/10.11648/j.cb.20150301.13
AB  - Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P  0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.
VL  - 3
IS  - 1
ER  -

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Author Information

Jimoh A.

Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria
Tanko Y.

Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria
Ahmed A.

Department of Pharmacognosy, Ahmadu Bello University, Zaria, Nigeria
Mohammed A.

Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria
Ayo J. O.

Department of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria, Nigeria

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APA Style

Jimoh A., Tanko Y., Ahmed A., Mohammed A., Ayo J. O. (2015). Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits. Cell Biology, 3(1), 19-24. https://doi.org/10.11648/j.cb.20150301.13

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ACS Style

Jimoh A.; Tanko Y.; Ahmed A.; Mohammed A.; Ayo J. O. Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits. Cell Biol. 2015, 3(1), 19-24. doi: 10.11648/j.cb.20150301.13

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AMA Style

Jimoh A., Tanko Y., Ahmed A., Mohammed A., Ayo J. O. Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits. Cell Biol. 2015;3(1):19-24. doi: 10.11648/j.cb.20150301.13

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@article{10.11648/j.cb.20150301.13,
  author = {Jimoh A. and Tanko Y. and Ahmed A. and Mohammed A. and Ayo J. O.},
  title = {Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits},
  journal = {Cell Biology},
  volume = {3},
  number = {1},
  pages = {19-24},
  doi = {10.11648/j.cb.20150301.13},
  url = {https://doi.org/10.11648/j.cb.20150301.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20150301.13},
  abstract = {Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P  0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits
AU  - Jimoh A.
AU  - Tanko Y.
AU  - Ahmed A.
AU  - Mohammed A.
AU  - Ayo J. O.
Y1  - 2015/02/02
PY  - 2015
N1  - https://doi.org/10.11648/j.cb.20150301.13
DO  - 10.11648/j.cb.20150301.13
T2  - Cell Biology
JF  - Cell Biology
JO  - Cell Biology
SP  - 19
EP  - 24
PB  - Science Publishing Group
SN  - 2330-0183
UR  - https://doi.org/10.11648/j.cb.20150301.13
AB  - Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P  0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.
VL  - 3
IS  - 1
ER  -

Copy | Download