Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years

David A. Areshidze; Lyudmila D. Timchenko; Maria A. Кozlova

doi:doi:10.11648/j.bio.20130104.11

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Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years

David A. Areshidze, Lyudmila D. Timchenko, Maria A. Кozlova

Published in American Journal of Bioscience and Bioengineering (Volume 1, Issue 4)

Received: 18 June 2013 Published: 20 August 2013

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Abstract

Researches of age-dependent changes of liver functions and their correction with the use of various biologically active substances are an important issue of modern biomedicine. Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of two years at its experimental toxic damage showed that the substrate has expressed a pronounced hepatoprotective effect. Under its influence morphological changes in the rat liver induced by CCl4 are much less pronounced than in the controls. There are also less significant deviations from normal levels of Alanine transamilase (ALT), Alanine transaminase AST and Total Bilirubin in blood plasma. Information analysis of the state of the organ indicates that the level of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum (L.) is significantly higher than at the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopathological analysis confirmed the alleviation of liver damage in connection with use of enzymatic hydrolyzate of Chlorophytum comosum (L.)

Published in	American Journal of Bioscience and Bioengineering (Volume 1, Issue 4)
DOI	10.11648/j.bio.20130104.11
Page(s)	49-54
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Liver, Hydrolizate, Hepatotoxicity, Hepatocyte, Chlorophytum Comosum (L.)

References

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David A. Areshidze, Lyudmila D. Timchenko, Maria A. Кozlova. (2013). Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years. American Journal of Bioscience and Bioengineering, 1(4), 49-54. https://doi.org/10.11648/j.bio.20130104.11

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ACS Style

David A. Areshidze; Lyudmila D. Timchenko; Maria A. Кozlova. Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years. Am. J. BioSci. Bioeng. 2013, 1(4), 49-54. doi: 10.11648/j.bio.20130104.11

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AMA Style

David A. Areshidze, Lyudmila D. Timchenko, Maria A. Кozlova. Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years. Am J BioSci Bioeng. 2013;1(4):49-54. doi: 10.11648/j.bio.20130104.11

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@article{10.11648/j.bio.20130104.11,
  author = {David A. Areshidze and Lyudmila D. Timchenko and Maria A. Кozlova},
  title = {Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {1},
  number = {4},
  pages = {49-54},
  doi = {10.11648/j.bio.20130104.11},
  url = {https://doi.org/10.11648/j.bio.20130104.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20130104.11},
  abstract = {Researches of age-dependent changes of liver functions and their correction with the use of various biologically active substances are an important issue of modern biomedicine. Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of two years at its experimental toxic damage showed that the substrate has expressed a pronounced hepatoprotective effect. Under its influence morphological changes in the rat liver induced by CCl4 are much less pronounced than in the controls. There are also less significant deviations from normal levels of Alanine transamilase (ALT), Alanine transaminase AST and Total Bilirubin in blood plasma. Information analysis of the state of the organ indicates that the level of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum (L.) is significantly higher than at the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopathological analysis confirmed the alleviation of liver damage in connection with use of enzymatic hydrolyzate of Chlorophytum comosum (L.)},
 year = {2013}
}

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TY  - JOUR
T1  - Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years
AU  - David A. Areshidze
AU  - Lyudmila D. Timchenko
AU  - Maria A. Кozlova
Y1  - 2013/08/20
PY  - 2013
N1  - https://doi.org/10.11648/j.bio.20130104.11
DO  - 10.11648/j.bio.20130104.11
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
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EP  - 54
PB  - Science Publishing Group
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AB  - Researches of age-dependent changes of liver functions and their correction with the use of various biologically active substances are an important issue of modern biomedicine. Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of two years at its experimental toxic damage showed that the substrate has expressed a pronounced hepatoprotective effect. Under its influence morphological changes in the rat liver induced by CCl4 are much less pronounced than in the controls. There are also less significant deviations from normal levels of Alanine transamilase (ALT), Alanine transaminase AST and Total Bilirubin in blood plasma. Information analysis of the state of the organ indicates that the level of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum (L.) is significantly higher than at the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopathological analysis confirmed the alleviation of liver damage in connection with use of enzymatic hydrolyzate of Chlorophytum comosum (L.)
VL  - 1
IS  - 4
ER  -

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Author Information

David A. Areshidze

Center of Cell Biology and Applied Biotechnology, Moscow State Regional University, Moscow, Russian Federation
Lyudmila D. Timchenko

North Caucasian federal university, Stavropol, Russian Federation
Maria A. Кozlova

Center of Cell Biology and Applied Biotechnology, Moscow State Regional University, Moscow, Russian Federation

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APA Style

David A. Areshidze, Lyudmila D. Timchenko, Maria A. Кozlova. (2013). Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years. American Journal of Bioscience and Bioengineering, 1(4), 49-54. https://doi.org/10.11648/j.bio.20130104.11

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ACS Style

David A. Areshidze; Lyudmila D. Timchenko; Maria A. Кozlova. Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years. Am. J. BioSci. Bioeng. 2013, 1(4), 49-54. doi: 10.11648/j.bio.20130104.11

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AMA Style

David A. Areshidze, Lyudmila D. Timchenko, Maria A. Кozlova. Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years. Am J BioSci Bioeng. 2013;1(4):49-54. doi: 10.11648/j.bio.20130104.11

Copy | Download

@article{10.11648/j.bio.20130104.11,
  author = {David A. Areshidze and Lyudmila D. Timchenko and Maria A. Кozlova},
  title = {Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {1},
  number = {4},
  pages = {49-54},
  doi = {10.11648/j.bio.20130104.11},
  url = {https://doi.org/10.11648/j.bio.20130104.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20130104.11},
  abstract = {Researches of age-dependent changes of liver functions and their correction with the use of various biologically active substances are an important issue of modern biomedicine. Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of two years at its experimental toxic damage showed that the substrate has expressed a pronounced hepatoprotective effect. Under its influence morphological changes in the rat liver induced by CCl4 are much less pronounced than in the controls. There are also less significant deviations from normal levels of Alanine transamilase (ALT), Alanine transaminase AST and Total Bilirubin in blood plasma. Information analysis of the state of the organ indicates that the level of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum (L.) is significantly higher than at the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopathological analysis confirmed the alleviation of liver damage in connection with use of enzymatic hydrolyzate of Chlorophytum comosum (L.)},
 year = {2013}
}

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TY  - JOUR
T1  - Protective Effect of Enzymatic Hydrolyzate of Chlorophytum Comosum (L.) against Experimental Toxic Liver Injury in Wistar Rats at the Age of Two Years
AU  - David A. Areshidze
AU  - Lyudmila D. Timchenko
AU  - Maria A. Кozlova
Y1  - 2013/08/20
PY  - 2013
N1  - https://doi.org/10.11648/j.bio.20130104.11
DO  - 10.11648/j.bio.20130104.11
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 49
EP  - 54
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20130104.11
AB  - Researches of age-dependent changes of liver functions and their correction with the use of various biologically active substances are an important issue of modern biomedicine. Investigation of the influence of the enzymatic hydrolyzate of Chlorophytum comosum (L.) on the liver of rats at the age of two years at its experimental toxic damage showed that the substrate has expressed a pronounced hepatoprotective effect. Under its influence morphological changes in the rat liver induced by CCl4 are much less pronounced than in the controls. There are also less significant deviations from normal levels of Alanine transamilase (ALT), Alanine transaminase AST and Total Bilirubin in blood plasma. Information analysis of the state of the organ indicates that the level of adaptation and regeneration opportunities of the liver of rats treated with an enzymatic hydrolyzate of Chlorophytum comosum (L.) is significantly higher than at the liver of rats with experimental toxic liver damage without the use of studied substrate. Histopathological analysis confirmed the alleviation of liver damage in connection with use of enzymatic hydrolyzate of Chlorophytum comosum (L.)
VL  - 1
IS  - 4
ER  -

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