Exposure to ionizing radiation leads to exhaustion of the pool of stem cells, increases differentiated cell stress, and activated reparation and apoptosis processes. Apart from well-documented acute effects, radiotherapy leads to delayed effects manifesting in few years after successful treatment. The aim of our study was the development of a test battery for evaluation of irradiation aftereffects in organisms characterized by different radiosensitivity. We chose C57BL mice as the ideal strain, because according to published data, they are characterized by medium radiosensitivity. At the preliminary stage, we have to assess informative value of some methods for the sublethal irradiation dose of 750 R. For evaluation of the damaging effects of radiation (lymphocyte count and maturity), we used, along with classical criteria, some complex parameters (body weight, serum homeostasis, behavior) characterizing general status of the organism. We also performed histological analysis of the liver, spleen, and pancreas and ranged the injuries by their severity.
| Published in |
American Journal of Life Sciences (Volume 3, Issue 1-2)
This article belongs to the Special Issue Space Flight Factors: From Cell to Body |
| DOI | 10.11648/j.ajls.s.2015030102.12 |
| Page(s) | 5-12 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Histological Examination, Complex of Tests, Laser Correlation Spectroscopy, Radiation
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APA Style
Irina Alchinova, Elena Arkhipova, Yulia Medvedeva, Anton Cherepov, Alexander Antipov, et al. (2014). The Complex of Tests for the Quantitative Evaluation of the Effects of Radiation on Laboratory Animals. American Journal of Life Sciences, 3(1-2), 5-12. https://doi.org/10.11648/j.ajls.s.2015030102.12
ACS Style
Irina Alchinova; Elena Arkhipova; Yulia Medvedeva; Anton Cherepov; Alexander Antipov, et al. The Complex of Tests for the Quantitative Evaluation of the Effects of Radiation on Laboratory Animals. Am. J. Life Sci. 2014, 3(1-2), 5-12. doi: 10.11648/j.ajls.s.2015030102.12
AMA Style
Irina Alchinova, Elena Arkhipova, Yulia Medvedeva, Anton Cherepov, Alexander Antipov, et al. The Complex of Tests for the Quantitative Evaluation of the Effects of Radiation on Laboratory Animals. Am J Life Sci. 2014;3(1-2):5-12. doi: 10.11648/j.ajls.s.2015030102.12
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Download@article{10.11648/j.ajls.s.2015030102.12,
author = {Irina Alchinova and Elena Arkhipova and Yulia Medvedeva and Anton Cherepov and Alexander Antipov and Nikolai Lysenko and Leonid Noskin and Mikhail Karganov},
title = {The Complex of Tests for the Quantitative Evaluation of the Effects of Radiation on Laboratory Animals},
journal = {American Journal of Life Sciences},
volume = {3},
number = {1-2},
pages = {5-12},
doi = {10.11648/j.ajls.s.2015030102.12},
url = {https://doi.org/10.11648/j.ajls.s.2015030102.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.s.2015030102.12},
abstract = {Exposure to ionizing radiation leads to exhaustion of the pool of stem cells, increases differentiated cell stress, and activated reparation and apoptosis processes. Apart from well-documented acute effects, radiotherapy leads to delayed effects manifesting in few years after successful treatment. The aim of our study was the development of a test battery for evaluation of irradiation aftereffects in organisms characterized by different radiosensitivity. We chose C57BL mice as the ideal strain, because according to published data, they are characterized by medium radiosensitivity. At the preliminary stage, we have to assess informative value of some methods for the sublethal irradiation dose of 750 R. For evaluation of the damaging effects of radiation (lymphocyte count and maturity), we used, along with classical criteria, some complex parameters (body weight, serum homeostasis, behavior) characterizing general status of the organism. We also performed histological analysis of the liver, spleen, and pancreas and ranged the injuries by their severity.},
year = {2014}
}
TY - JOUR T1 - The Complex of Tests for the Quantitative Evaluation of the Effects of Radiation on Laboratory Animals AU - Irina Alchinova AU - Elena Arkhipova AU - Yulia Medvedeva AU - Anton Cherepov AU - Alexander Antipov AU - Nikolai Lysenko AU - Leonid Noskin AU - Mikhail Karganov Y1 - 2014/11/14 PY - 2014 N1 - https://doi.org/10.11648/j.ajls.s.2015030102.12 DO - 10.11648/j.ajls.s.2015030102.12 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 5 EP - 12 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.s.2015030102.12 AB - Exposure to ionizing radiation leads to exhaustion of the pool of stem cells, increases differentiated cell stress, and activated reparation and apoptosis processes. Apart from well-documented acute effects, radiotherapy leads to delayed effects manifesting in few years after successful treatment. The aim of our study was the development of a test battery for evaluation of irradiation aftereffects in organisms characterized by different radiosensitivity. We chose C57BL mice as the ideal strain, because according to published data, they are characterized by medium radiosensitivity. At the preliminary stage, we have to assess informative value of some methods for the sublethal irradiation dose of 750 R. For evaluation of the damaging effects of radiation (lymphocyte count and maturity), we used, along with classical criteria, some complex parameters (body weight, serum homeostasis, behavior) characterizing general status of the organism. We also performed histological analysis of the liver, spleen, and pancreas and ranged the injuries by their severity. VL - 3 IS - 1-2 ER -
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