Background: Diabetic nephropathy has become the leading cause of end-stage renal failure in Europe, the United States and Japan (25-44%). Chemerin is a chemoattractant expressed in white adipose, liver and lung tissues. Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. The aim of the present work is to estimate serum chemerin level and to correlate its level in the patients with the stage of the diabetic nephropathy disease. Patients and Methods: The present study included 60 subjects who were divided into 4 groups Group I: included 15 diabetic patients with norm albuminuria Group II: included 15 diabetic patients with microalbuminuria Group III: included 15 diabetic patients with macroalbuminuria Group IV: included 15 normal subjects as a control group. All patients and controls were subjected to estimation of body mass index. Blood urea, serum creatinine and estimated GFR, Urinary albumin to urinary creatinine ratio, complete lipid profile (LDL, HDL, TG) and Serum chemerin level by ELIZA. Results: Serum chemerin level was higher in diabetic than non-diabetic persons and was higher in patients with macroalbuminuria than those with normo and microalbuminuria and its level is correlated with markers of impaired renal function. Conclusion: chemerin could have a role in progression of diabetic nephropathy or its level could be elevated due to impaired renal excretion which should be further investigated.
| Published in |
American Journal of Internal Medicine (Volume 4, Issue 2-1)
This article belongs to the Special Issue Different Medical Research From Middle East |
| DOI | 10.11648/j.ajim.s.2016040201.13 |
| Page(s) | 13-17 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Diabetic Nephropathy, Chemerin, Albuminuria
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APA Style
Iman E. El-Gohary, Azza Abedl-Karim, Doaa I. Hashad. (2015). Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy. American Journal of Internal Medicine, 4(2-1), 13-17. https://doi.org/10.11648/j.ajim.s.2016040201.13
ACS Style
Iman E. El-Gohary; Azza Abedl-Karim; Doaa I. Hashad. Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy. Am. J. Intern. Med. 2015, 4(2-1), 13-17. doi: 10.11648/j.ajim.s.2016040201.13
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Download@article{10.11648/j.ajim.s.2016040201.13,
author = {Iman E. El-Gohary and Azza Abedl-Karim and Doaa I. Hashad},
title = {Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy},
journal = {American Journal of Internal Medicine},
volume = {4},
number = {2-1},
pages = {13-17},
doi = {10.11648/j.ajim.s.2016040201.13},
url = {https://doi.org/10.11648/j.ajim.s.2016040201.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.s.2016040201.13},
abstract = {Background: Diabetic nephropathy has become the leading cause of end-stage renal failure in Europe, the United States and Japan (25-44%). Chemerin is a chemoattractant expressed in white adipose, liver and lung tissues. Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. The aim of the present work is to estimate serum chemerin level and to correlate its level in the patients with the stage of the diabetic nephropathy disease. Patients and Methods: The present study included 60 subjects who were divided into 4 groups Group I: included 15 diabetic patients with norm albuminuria Group II: included 15 diabetic patients with microalbuminuria Group III: included 15 diabetic patients with macroalbuminuria Group IV: included 15 normal subjects as a control group. All patients and controls were subjected to estimation of body mass index. Blood urea, serum creatinine and estimated GFR, Urinary albumin to urinary creatinine ratio, complete lipid profile (LDL, HDL, TG) and Serum chemerin level by ELIZA. Results: Serum chemerin level was higher in diabetic than non-diabetic persons and was higher in patients with macroalbuminuria than those with normo and microalbuminuria and its level is correlated with markers of impaired renal function. Conclusion: chemerin could have a role in progression of diabetic nephropathy or its level could be elevated due to impaired renal excretion which should be further investigated.},
year = {2015}
}
TY - JOUR T1 - Serum Chemerin Level: Does It Have a Role in Progression of Diabetic Nephropathy AU - Iman E. El-Gohary AU - Azza Abedl-Karim AU - Doaa I. Hashad Y1 - 2015/11/30 PY - 2015 N1 - https://doi.org/10.11648/j.ajim.s.2016040201.13 DO - 10.11648/j.ajim.s.2016040201.13 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 13 EP - 17 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.s.2016040201.13 AB - Background: Diabetic nephropathy has become the leading cause of end-stage renal failure in Europe, the United States and Japan (25-44%). Chemerin is a chemoattractant expressed in white adipose, liver and lung tissues. Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. The aim of the present work is to estimate serum chemerin level and to correlate its level in the patients with the stage of the diabetic nephropathy disease. Patients and Methods: The present study included 60 subjects who were divided into 4 groups Group I: included 15 diabetic patients with norm albuminuria Group II: included 15 diabetic patients with microalbuminuria Group III: included 15 diabetic patients with macroalbuminuria Group IV: included 15 normal subjects as a control group. All patients and controls were subjected to estimation of body mass index. Blood urea, serum creatinine and estimated GFR, Urinary albumin to urinary creatinine ratio, complete lipid profile (LDL, HDL, TG) and Serum chemerin level by ELIZA. Results: Serum chemerin level was higher in diabetic than non-diabetic persons and was higher in patients with macroalbuminuria than those with normo and microalbuminuria and its level is correlated with markers of impaired renal function. Conclusion: chemerin could have a role in progression of diabetic nephropathy or its level could be elevated due to impaired renal excretion which should be further investigated. VL - 4 IS - 2-1 ER -
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