Outcome of Paraquat Self-poisoning a Case series

M Indira; Rakesh T P; Hithesh Shankar T S; Suchithra E T; Andrews M A

doi:doi:10.11648/j.ajim.s.2015030601.11

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Outcome of Paraquat Self-poisoning a Case series

M Indira, Rakesh T P, Hithesh Shankar T S, Suchithra E T, Andrews M A

Published in American Journal of Internal Medicine (Volume 3, Issue 6-1)

Received: 29 March 2015 Accepted: 9 April 2015 Published: 23 October 2015

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Abstract

Introduction –Paraquat is available as 20% solution for agricultural purposes and deliberate ingestion can be lethal despite newer modalities of management.Methods - We present a case series from a tertiary care hospital, consisting of six patients admitted from January 2012 to December 2013 with history of paraquat ingestion. All of them weretreated with supportive and specific care in the form of charcoal hemoperfusion (HP) and immunosuppression with cyclophosphamide and steroids and outcome was evaluated.Results - All patients developed respiratory, renal and hepatic dysfunction. Three patients died within one week of paraquat ingestion, two patients at the end of second week and one patient lost follow-up after discharge. Autopsy showed ARDS in three of them.Conclusion -Paraquat is highly toxic. Ingestion of concentrated form most likely results in non responsiveness to available modalities of treatment.

Published in	American Journal of Internal Medicine (Volume 3, Issue 6-1) This article belongs to the Special Issue Toxicology
DOI	10.11648/j.ajim.s.2015030601.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Paraquat, Charcol hemoperfusion, Immunosuppressive therapy, ARDS, Renal and hepatic dysfunction

References

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APA Style

M Indira, Rakesh T P, Hithesh Shankar T S, Suchithra E T, Andrews M A. (2015). Outcome of Paraquat Self-poisoning a Case series. American Journal of Internal Medicine, 3(6-1), 1-4. https://doi.org/10.11648/j.ajim.s.2015030601.11

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ACS Style

M Indira; Rakesh T P; Hithesh Shankar T S; Suchithra E T; Andrews M A. Outcome of Paraquat Self-poisoning a Case series. Am. J. Intern. Med. 2015, 3(6-1), 1-4. doi: 10.11648/j.ajim.s.2015030601.11

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AMA Style

M Indira, Rakesh T P, Hithesh Shankar T S, Suchithra E T, Andrews M A. Outcome of Paraquat Self-poisoning a Case series. Am J Intern Med. 2015;3(6-1):1-4. doi: 10.11648/j.ajim.s.2015030601.11

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@article{10.11648/j.ajim.s.2015030601.11,
  author = {M Indira and Rakesh T P and Hithesh Shankar T S and Suchithra E T and Andrews M A},
  title = {Outcome of Paraquat Self-poisoning a Case series},
  journal = {American Journal of Internal Medicine},
  volume = {3},
  number = {6-1},
  pages = {1-4},
  doi = {10.11648/j.ajim.s.2015030601.11},
  url = {https://doi.org/10.11648/j.ajim.s.2015030601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.s.2015030601.11},
  abstract = {Introduction –Paraquat is available as 20% solution for agricultural purposes and deliberate ingestion can be lethal despite newer modalities of management.Methods - We present a case series from a tertiary care hospital, consisting of six patients admitted from January 2012 to December 2013 with history of paraquat ingestion. All of them weretreated with supportive and specific care in the form of charcoal hemoperfusion (HP) and immunosuppression with cyclophosphamide and steroids and outcome was evaluated.Results - All patients developed respiratory, renal and hepatic dysfunction. Three patients died within one week of paraquat ingestion, two patients at the end of second week and one patient lost follow-up after discharge. Autopsy showed ARDS in three of them.Conclusion -Paraquat is highly toxic. Ingestion of concentrated form most likely results in non responsiveness to available modalities of treatment.},
 year = {2015}
}

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TY  - JOUR
T1  - Outcome of Paraquat Self-poisoning a Case series
AU  - M Indira
AU  - Rakesh T P
AU  - Hithesh Shankar T S
AU  - Suchithra E T
AU  - Andrews M A
Y1  - 2015/10/23
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.s.2015030601.11
DO  - 10.11648/j.ajim.s.2015030601.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.s.2015030601.11
AB  - Introduction –Paraquat is available as 20% solution for agricultural purposes and deliberate ingestion can be lethal despite newer modalities of management.Methods - We present a case series from a tertiary care hospital, consisting of six patients admitted from January 2012 to December 2013 with history of paraquat ingestion. All of them weretreated with supportive and specific care in the form of charcoal hemoperfusion (HP) and immunosuppression with cyclophosphamide and steroids and outcome was evaluated.Results - All patients developed respiratory, renal and hepatic dysfunction. Three patients died within one week of paraquat ingestion, two patients at the end of second week and one patient lost follow-up after discharge. Autopsy showed ARDS in three of them.Conclusion -Paraquat is highly toxic. Ingestion of concentrated form most likely results in non responsiveness to available modalities of treatment.
VL  - 3
IS  - 6-1
ER  -

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Author Information

M Indira

Department of Medicine, Government Medical College, Thrissur, Kerala, India
Rakesh T P

Department of Medicine, Government Medical College, Thrissur, Kerala, India
Hithesh Shankar T S

Department of Forensic medicine, Government Medical College, Thrissur, Kerala, India
Suchithra E T

Department of Community medicine, Government Medical College, Thrissur, Kerala, India
Andrews M A

Department of Medicine, Government Medical College, Thrissur, Kerala, India

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Plain Text BibTeX RIS

APA Style

M Indira, Rakesh T P, Hithesh Shankar T S, Suchithra E T, Andrews M A. (2015). Outcome of Paraquat Self-poisoning a Case series. American Journal of Internal Medicine, 3(6-1), 1-4. https://doi.org/10.11648/j.ajim.s.2015030601.11

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ACS Style

M Indira; Rakesh T P; Hithesh Shankar T S; Suchithra E T; Andrews M A. Outcome of Paraquat Self-poisoning a Case series. Am. J. Intern. Med. 2015, 3(6-1), 1-4. doi: 10.11648/j.ajim.s.2015030601.11

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AMA Style

M Indira, Rakesh T P, Hithesh Shankar T S, Suchithra E T, Andrews M A. Outcome of Paraquat Self-poisoning a Case series. Am J Intern Med. 2015;3(6-1):1-4. doi: 10.11648/j.ajim.s.2015030601.11

Copy | Download

@article{10.11648/j.ajim.s.2015030601.11,
  author = {M Indira and Rakesh T P and Hithesh Shankar T S and Suchithra E T and Andrews M A},
  title = {Outcome of Paraquat Self-poisoning a Case series},
  journal = {American Journal of Internal Medicine},
  volume = {3},
  number = {6-1},
  pages = {1-4},
  doi = {10.11648/j.ajim.s.2015030601.11},
  url = {https://doi.org/10.11648/j.ajim.s.2015030601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.s.2015030601.11},
  abstract = {Introduction –Paraquat is available as 20% solution for agricultural purposes and deliberate ingestion can be lethal despite newer modalities of management.Methods - We present a case series from a tertiary care hospital, consisting of six patients admitted from January 2012 to December 2013 with history of paraquat ingestion. All of them weretreated with supportive and specific care in the form of charcoal hemoperfusion (HP) and immunosuppression with cyclophosphamide and steroids and outcome was evaluated.Results - All patients developed respiratory, renal and hepatic dysfunction. Three patients died within one week of paraquat ingestion, two patients at the end of second week and one patient lost follow-up after discharge. Autopsy showed ARDS in three of them.Conclusion -Paraquat is highly toxic. Ingestion of concentrated form most likely results in non responsiveness to available modalities of treatment.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Outcome of Paraquat Self-poisoning a Case series
AU  - M Indira
AU  - Rakesh T P
AU  - Hithesh Shankar T S
AU  - Suchithra E T
AU  - Andrews M A
Y1  - 2015/10/23
PY  - 2015
N1  - https://doi.org/10.11648/j.ajim.s.2015030601.11
DO  - 10.11648/j.ajim.s.2015030601.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.s.2015030601.11
AB  - Introduction –Paraquat is available as 20% solution for agricultural purposes and deliberate ingestion can be lethal despite newer modalities of management.Methods - We present a case series from a tertiary care hospital, consisting of six patients admitted from January 2012 to December 2013 with history of paraquat ingestion. All of them weretreated with supportive and specific care in the form of charcoal hemoperfusion (HP) and immunosuppression with cyclophosphamide and steroids and outcome was evaluated.Results - All patients developed respiratory, renal and hepatic dysfunction. Three patients died within one week of paraquat ingestion, two patients at the end of second week and one patient lost follow-up after discharge. Autopsy showed ARDS in three of them.Conclusion -Paraquat is highly toxic. Ingestion of concentrated form most likely results in non responsiveness to available modalities of treatment.
VL  - 3
IS  - 6-1
ER  -

Copy | Download