Background and Objectives: Oxidative stress and inflammation are cooperative events involved in essential hypertension diseases. This study was as a step for elucidating the contribution of N-terminal pro-brain natriuretic peptide, matrix-metalloprotinase-9 and 8-oxo2-deoxyguanosine with the essential hypertension incidence, development, and progression. Aims: The objective was to determine the serum studied parameters levels in essential hypertensive and normotensive subjects, and to assess the association between these biomarkers with the essential hypertension, and to investigate the effect of other confounding factors like stages, age, and gender and finally find the correlation between all studied parameters. Methods: This study was designed to examine the associations between the focused parameters with the essential hypertension on 50 patients of both genders, as well as an equal numbers of matched age–gender healthy adults were also enrolled in this study as a control group. The hypothesis suggesting that oxidative stress and inflammatory processes influence the risk of adverse clinical outcomes are worth investigating. These parameters were analyzed using enzyme linked immunosorbent assay. Statistical analyses were performed with SPSS version 18. Results: Patients with essential hypertension exhibited significantly higher serum focused parameters levels as compared with the control group. The mean serum N-terminal pro–brain natriuretic peptide levels in patients and control groups were 304.33 ± 204.19, 76.52±20.98 pg/ml respectively. The mean serum matrix–metalloprotinase-9 level in patients and control groups were 2.36±1.1, 1.4±0.8 respectively. The mean serum 8-oxo-2-deoxy guanosine level in patients and control groups were 170.40±41.95, 84.11±34.07 (mg/ml) respectively. Conclusions: Data suggested an association between these circulating biomarkers with the incidence, development, and progression of essential hypertension. No effect of age and gender present on serum levels of focused biomarkers in both groups. These focused parameters seem to be a simple, non-invasive tools and independent parameters for early detection, assessing disease severity, and involved in the etiology of disease. Data indicated an alteration in the oxidative status and inflammatory processes in patients with essential hypertension. Accordingly, this work was undertaken to assess contribution of the oxidative stress and inflammatory process as a risk factors. In addition, these parameters are regarded as markers with prognostic significance and as potential therapeutic targets. These biomarkers are tools that might aid the physicians in diagnosis and subsequent risk stratification, guiding selection of therapy, secondary prevention, and serving as a target for therapy.
| Published in | American Journal of Internal Medicine (Volume 3, Issue 2) |
| DOI | 10.11648/j.ajim.20150302.14 |
| Page(s) | 67-77 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Essential Hypertension, N-Terminal Pro-Brain Natriuretic Peptide, Matrix-Metalloprotinase-9, 8-Oxo2-Deoxyguanosine
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APA Style
Julian Yonan Ismaeil, Shatha Rouf Moustafa. (2015). Association of N-Terminal Pro–Brain Natriuretic Peptide, Matrix –Metalloprotinase-9, and 8-Oxo-2 Deoxy Guanosine with the Incidence of Essential Hypertension. American Journal of Internal Medicine, 3(2), 67-77. https://doi.org/10.11648/j.ajim.20150302.14
ACS Style
Julian Yonan Ismaeil; Shatha Rouf Moustafa. Association of N-Terminal Pro–Brain Natriuretic Peptide, Matrix –Metalloprotinase-9, and 8-Oxo-2 Deoxy Guanosine with the Incidence of Essential Hypertension. Am. J. Intern. Med. 2015, 3(2), 67-77. doi: 10.11648/j.ajim.20150302.14
AMA Style
Julian Yonan Ismaeil, Shatha Rouf Moustafa. Association of N-Terminal Pro–Brain Natriuretic Peptide, Matrix –Metalloprotinase-9, and 8-Oxo-2 Deoxy Guanosine with the Incidence of Essential Hypertension. Am J Intern Med. 2015;3(2):67-77. doi: 10.11648/j.ajim.20150302.14
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Download@article{10.11648/j.ajim.20150302.14,
author = {Julian Yonan Ismaeil and Shatha Rouf Moustafa},
title = {Association of N-Terminal Pro–Brain Natriuretic Peptide, Matrix –Metalloprotinase-9, and 8-Oxo-2 Deoxy Guanosine with the Incidence of Essential Hypertension},
journal = {American Journal of Internal Medicine},
volume = {3},
number = {2},
pages = {67-77},
doi = {10.11648/j.ajim.20150302.14},
url = {https://doi.org/10.11648/j.ajim.20150302.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20150302.14},
abstract = {Background and Objectives: Oxidative stress and inflammation are cooperative events involved in essential hypertension diseases. This study was as a step for elucidating the contribution of N-terminal pro-brain natriuretic peptide, matrix-metalloprotinase-9 and 8-oxo2-deoxyguanosine with the essential hypertension incidence, development, and progression. Aims: The objective was to determine the serum studied parameters levels in essential hypertensive and normotensive subjects, and to assess the association between these biomarkers with the essential hypertension, and to investigate the effect of other confounding factors like stages, age, and gender and finally find the correlation between all studied parameters. Methods: This study was designed to examine the associations between the focused parameters with the essential hypertension on 50 patients of both genders, as well as an equal numbers of matched age–gender healthy adults were also enrolled in this study as a control group. The hypothesis suggesting that oxidative stress and inflammatory processes influence the risk of adverse clinical outcomes are worth investigating. These parameters were analyzed using enzyme linked immunosorbent assay. Statistical analyses were performed with SPSS version 18. Results: Patients with essential hypertension exhibited significantly higher serum focused parameters levels as compared with the control group. The mean serum N-terminal pro–brain natriuretic peptide levels in patients and control groups were 304.33 ± 204.19, 76.52±20.98 pg/ml respectively. The mean serum matrix–metalloprotinase-9 level in patients and control groups were 2.36±1.1, 1.4±0.8 respectively. The mean serum 8-oxo-2-deoxy guanosine level in patients and control groups were 170.40±41.95, 84.11±34.07 (mg/ml) respectively. Conclusions: Data suggested an association between these circulating biomarkers with the incidence, development, and progression of essential hypertension. No effect of age and gender present on serum levels of focused biomarkers in both groups. These focused parameters seem to be a simple, non-invasive tools and independent parameters for early detection, assessing disease severity, and involved in the etiology of disease. Data indicated an alteration in the oxidative status and inflammatory processes in patients with essential hypertension. Accordingly, this work was undertaken to assess contribution of the oxidative stress and inflammatory process as a risk factors. In addition, these parameters are regarded as markers with prognostic significance and as potential therapeutic targets. These biomarkers are tools that might aid the physicians in diagnosis and subsequent risk stratification, guiding selection of therapy, secondary prevention, and serving as a target for therapy.},
year = {2015}
}
TY - JOUR T1 - Association of N-Terminal Pro–Brain Natriuretic Peptide, Matrix –Metalloprotinase-9, and 8-Oxo-2 Deoxy Guanosine with the Incidence of Essential Hypertension AU - Julian Yonan Ismaeil AU - Shatha Rouf Moustafa Y1 - 2015/03/23 PY - 2015 N1 - https://doi.org/10.11648/j.ajim.20150302.14 DO - 10.11648/j.ajim.20150302.14 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 67 EP - 77 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20150302.14 AB - Background and Objectives: Oxidative stress and inflammation are cooperative events involved in essential hypertension diseases. This study was as a step for elucidating the contribution of N-terminal pro-brain natriuretic peptide, matrix-metalloprotinase-9 and 8-oxo2-deoxyguanosine with the essential hypertension incidence, development, and progression. Aims: The objective was to determine the serum studied parameters levels in essential hypertensive and normotensive subjects, and to assess the association between these biomarkers with the essential hypertension, and to investigate the effect of other confounding factors like stages, age, and gender and finally find the correlation between all studied parameters. Methods: This study was designed to examine the associations between the focused parameters with the essential hypertension on 50 patients of both genders, as well as an equal numbers of matched age–gender healthy adults were also enrolled in this study as a control group. The hypothesis suggesting that oxidative stress and inflammatory processes influence the risk of adverse clinical outcomes are worth investigating. These parameters were analyzed using enzyme linked immunosorbent assay. Statistical analyses were performed with SPSS version 18. Results: Patients with essential hypertension exhibited significantly higher serum focused parameters levels as compared with the control group. The mean serum N-terminal pro–brain natriuretic peptide levels in patients and control groups were 304.33 ± 204.19, 76.52±20.98 pg/ml respectively. The mean serum matrix–metalloprotinase-9 level in patients and control groups were 2.36±1.1, 1.4±0.8 respectively. The mean serum 8-oxo-2-deoxy guanosine level in patients and control groups were 170.40±41.95, 84.11±34.07 (mg/ml) respectively. Conclusions: Data suggested an association between these circulating biomarkers with the incidence, development, and progression of essential hypertension. No effect of age and gender present on serum levels of focused biomarkers in both groups. These focused parameters seem to be a simple, non-invasive tools and independent parameters for early detection, assessing disease severity, and involved in the etiology of disease. Data indicated an alteration in the oxidative status and inflammatory processes in patients with essential hypertension. Accordingly, this work was undertaken to assess contribution of the oxidative stress and inflammatory process as a risk factors. In addition, these parameters are regarded as markers with prognostic significance and as potential therapeutic targets. These biomarkers are tools that might aid the physicians in diagnosis and subsequent risk stratification, guiding selection of therapy, secondary prevention, and serving as a target for therapy. VL - 3 IS - 2 ER -
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