There are seven SIRT isoforms in mammals, with different biological activities including gene regulation, metabolism and apoptosis. Despite recent controversy about sirtuins function in some organisms, among them SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. SIRT3 is a member of the sirtuin family of NAD+ dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues. It is an endogenous negative regulator of cardiac hypertrophy, which protects hearts by suppressing cellular levels of ROS and modulates mitochondrial intermediary metabolism and fatty acid utilization during fasting. Another one, Hydrogen sulfide is produced within the human body, and relaxes the vascular endothelium and smooth muscle cells, which is important to maintaining clean arteries as one age. It functions as an antioxidant and inhibits expression of pro-inflammatory factors, all of which imply an important role in aging and age-associated diseases. The aim of this review is to find out the anti aging properties of SIRT3 and H2S that can be used to extend the life span of human as a preventive and therapeutic agent.
| Published in | American Journal of BioScience (Volume 2, Issue 6) |
| DOI | 10.11648/j.ajbio.20140206.16 |
| Page(s) | 222-232 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
SIRT3, H2S, ROS, Aging
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APA Style
Md. Shamim Hossain, Md. Ashrafuzzaman Sapon, Naim Hassan. (2014). Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases. American Journal of BioScience, 2(6), 222-232. https://doi.org/10.11648/j.ajbio.20140206.16
ACS Style
Md. Shamim Hossain; Md. Ashrafuzzaman Sapon; Naim Hassan. Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases. Am. J. BioScience 2014, 2(6), 222-232. doi: 10.11648/j.ajbio.20140206.16
AMA Style
Md. Shamim Hossain, Md. Ashrafuzzaman Sapon, Naim Hassan. Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases. Am J BioScience. 2014;2(6):222-232. doi: 10.11648/j.ajbio.20140206.16
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Download@article{10.11648/j.ajbio.20140206.16,
author = {Md. Shamim Hossain and Md. Ashrafuzzaman Sapon and Naim Hassan},
title = {Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases},
journal = {American Journal of BioScience},
volume = {2},
number = {6},
pages = {222-232},
doi = {10.11648/j.ajbio.20140206.16},
url = {https://doi.org/10.11648/j.ajbio.20140206.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20140206.16},
abstract = {There are seven SIRT isoforms in mammals, with different biological activities including gene regulation, metabolism and apoptosis. Despite recent controversy about sirtuins function in some organisms, among them SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. SIRT3 is a member of the sirtuin family of NAD+ dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues. It is an endogenous negative regulator of cardiac hypertrophy, which protects hearts by suppressing cellular levels of ROS and modulates mitochondrial intermediary metabolism and fatty acid utilization during fasting. Another one, Hydrogen sulfide is produced within the human body, and relaxes the vascular endothelium and smooth muscle cells, which is important to maintaining clean arteries as one age. It functions as an antioxidant and inhibits expression of pro-inflammatory factors, all of which imply an important role in aging and age-associated diseases. The aim of this review is to find out the anti aging properties of SIRT3 and H2S that can be used to extend the life span of human as a preventive and therapeutic agent.},
year = {2014}
}
TY - JOUR T1 - Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases AU - Md. Shamim Hossain AU - Md. Ashrafuzzaman Sapon AU - Naim Hassan Y1 - 2014/12/18 PY - 2014 N1 - https://doi.org/10.11648/j.ajbio.20140206.16 DO - 10.11648/j.ajbio.20140206.16 T2 - American Journal of BioScience JF - American Journal of BioScience JO - American Journal of BioScience SP - 222 EP - 232 PB - Science Publishing Group SN - 2330-0167 UR - https://doi.org/10.11648/j.ajbio.20140206.16 AB - There are seven SIRT isoforms in mammals, with different biological activities including gene regulation, metabolism and apoptosis. Despite recent controversy about sirtuins function in some organisms, among them SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. SIRT3 is a member of the sirtuin family of NAD+ dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues. It is an endogenous negative regulator of cardiac hypertrophy, which protects hearts by suppressing cellular levels of ROS and modulates mitochondrial intermediary metabolism and fatty acid utilization during fasting. Another one, Hydrogen sulfide is produced within the human body, and relaxes the vascular endothelium and smooth muscle cells, which is important to maintaining clean arteries as one age. It functions as an antioxidant and inhibits expression of pro-inflammatory factors, all of which imply an important role in aging and age-associated diseases. The aim of this review is to find out the anti aging properties of SIRT3 and H2S that can be used to extend the life span of human as a preventive and therapeutic agent. VL - 2 IS - 6 ER -
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